CAS: 15295-77-9; (S)-3-Aminodihydrofuran-2(3H)-One Hydrobromide

相似化合物

2185-03-7 110045-70-0 104347-13-9

上下游产品

L-methionine bromoacetic acid (S)-methioninol (S)-2-Benzyloxycarbonylamino-4-((S)-2-oxo-tetrahydro-furan-3-ylamino)-butyric acid tert-butyl ester (S)-2-benzoylamino-γ-butyrolactone tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate (2S)-2-amino-4-bromobutanoic acid hydrobromide

L-蛋氨酸置于溴乙酸体系中,用 水,溶剂黄146,异丙醇 用作溶剂,以86%的收率获得高丝氨酸内酯氢溴酸盐
参考文献:作为群体感应调节剂的含三唑的 N-酰基高丝氨酸内酯的合成和生物学评价†
标题:作为群体感应调节剂的含三唑的 N-酰基高丝氨酸内酯的合成和生物学评价†
摘要:许多细菌物种能够通过称为群体感应 (Qs) 的细胞-细胞信号传导机制评估其局部种群密度.这种细胞间通讯过程是由小分子或肽配体及其同源蛋白受体介导的.许多病原体一旦在宿主上达到阈值细胞数,就会使用 Qs 来启动毒力.因此,拦截 Qs 的方法作为潜在的抗感染疗法引起了相当多的关注.我们对开发小分子工具来调节 Qs 通路的兴趣促使我们评估天然n-酰基l 的含三唑类似物-高丝氨酸内酯 (Ahl) 在革兰氏阴性菌中作为非天然 Qs 激动剂和拮抗剂发出信号.我们使用有效的 Cu( I ) 催化的叠氮化物-炔烃偶联以高产率和高纯度合成了 72 种具有五种广泛结构类型的三唑衍生物.评估了这些化合物激活或抑制来自两种流行病原体的两种 Qs 受体的能力--来自铜绿假单胞菌的lasr和来自鲍曼不动杆菌的abar-使用细菌报告菌株.鉴定了几种能够强烈调节 Lasr 和 Abar 活性的三唑衍生物.这些化合物代表了一类新的,可合成的
Doi:10.1039/c2Ob27155A

专利信息

专利号:US-2024270683-A1
优先权日:2021-06-17
标题 :A process for preparation of an intermediate of l-glufosinate
发明人：MUDALIAR CHANDRASEKHAR DAYAL; MISHRA ASHISHKUMAR RAVINDRA
权利人:MUDALIAR CHANDRASEKHAR DAYAL; MISHRA ASHISHKUMAR RAVINDRA
摘要:The present invention provides a process for preparation of compound of formula (I), a key intermediate in synthesis of L-glufosinate or its salt. wherein P2 is an amino-protecting group; R1 is hydrogen, substituted or unsubstituted C1 to C6 alkyl group, a substituted or unsubstituted C1 to C6 alkenyl group, a substituted or unsubstituted C1 to C6 alkynyl group, a substituted or unsubstituted C3 to C10 cycloalkyl group, a substituted or unsubstituted C6 to C20 aryl group, or a substituted or unsubstituted C2 to C10 heteroaryl group; and X is a halogen or hydroxyl group.

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.