CAS: 18595-18-1; Methyl 3-Amino-4-Methylbenzoate

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CAS号7356-11-8 3-硝基-4-甲基苯甲酸甲酯 | CAS号96-98-0 4-甲基-3-硝基苯甲酸 | CAS号104901-43-1 3-溴-4-甲基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号2458-12-0 3-氨基-4-甲基苯甲酸 | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号90347-66-3 3-碘-4-甲基苯甲酸甲酯 | CAS号81863-45-8 3-氨基-4-甲基苯甲醇 | CAS号231958-04-6 3-((叔丁氧基羰基)氨基)-... | CAS号885518-82-1 3-碘吲唑-6-甲酸甲酯 | CAS号641571-10-0 尼罗替尼 | CAS号1025716-99-7 3-[(氨基亚胺甲基)氨基]-... | CAS号170487-40-8 1H-吲唑-6-羧酸甲酯 | CAS号845884-82-4 3-AMINO-4-METHY... | CAS号88072-06-4 methyl 3-(3-bro... | CAS号88072-16-6 methyl 4-methyl...

4-甲基-3-硝基苯甲酸置于硫酸,铁粉,氯化铵体系中,用 乙醇,水 用作溶剂,化学反应 21.0H,反应生成3-氨基-4-甲基苯甲酸甲酯
参考文献:新型 P2X7 拮抗剂的设计,合成和体外评估.
标题:新型 P2X7 拮抗剂的设计,合成和体外评估.
摘要:由于 P2X7 受体在炎症和免疫细胞信号传导中的重要作用,它是治疗各种疾病的有希望的靶点.这项工作描述了一系列带有多种支架的新型衍生物作为有效的 P2X7 拮抗剂的设计,合成和体外评估.我们的方法基于已报道的(金刚烷-1-基)甲基苯甲酰胺的结构修饰,能够抑制受体激活.金刚烷部分和酰胺键被替换,并通过基于配体的药效团模型评估替换.通过双电极电压钳实验评估合成类似物的拮抗效力,使用非洲爪蟾表达人 P2X7 受体的卵母细胞.Sar 研究表明,用芳基-环己基部分取代金刚烷环是对抗 P2X7 阳离子通道激活的最有效拮抗剂,类似物 2-氯-N-[1-(3-(硝基氧基甲基)苯基)环己基)甲基]苯甲酰胺 ( 56 ) 表现出最佳效力,Ic 50值为 0.39 μm.
Doi:10.1002/cmdc.202000303

专利信息

专利号:US-7129357-B2
优先权日:2003-09-15
标题:Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors
发明人：ANDREWS DAVID R; TANG SUHAN; WU WENXUE; KALLINEY SAMI Y; SUDHAKAR ANANTHA; NIELSEN CHRISTOPHER
权利人:SCHERING CORP
摘要:In one embodiment, the present application discloses a process for making the compound of the formula:

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors