CAS: 385425-15-0; 1-(4-Iodophenyl)Piperidin-2-One

上下游产品

N-苯基哌啶 N-Phenyl Piperidine 4096-20-2

N-苯基哌啶置于水,碘,碳酸氢钠体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以54%的收率获得1-(4-碘苯基)-2-哌啶酮
参考文献:无过渡金属的胺氧化:内酰胺后期形成的化学选择性策略
标题:无过渡金属的胺氧化:内酰胺后期形成的化学选择性策略
摘要:描述了通过选择性氧化环状仲和叔胺形成内酰胺的无金属策略.分子碘促进与环胺直接相邻的c-h键的化学选择性和区域选择性氧化.使用包括临床批准的药物支架在内的各种多样的小分子环胺,证明了其温和的条件,官能团耐受性和底物范围.
Doi:10.1021/acs.Orglett.7B00021

专利信息

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:US-2006025421-A1
优先权日:2004-06-25
标 题:Pyridyl piperazines for the treatment of CNS disorders
发明人：BRODNEY MICHAEL A
权利人:PFIZER
摘要:This invention is directed to compounds of Formula I and to pharmaceutical compositions comprising the compound of Formula I. n n where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar 1 , Ar 2 , . . . and Z are as defined in the specification. The invention is also directed to a method of treating a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, such as migraine, headache, cluster headache, anxiety, depression, etc. This invention is also directed to intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2005245566-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:EP-1467984-A2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo (3,4-c) pyrid-2-ones

专利号:US-2007027186-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones