CAS: 407-97-6; 1-Bromo-5-Fluoropentane

相似化合物

462-72-6 111-24-0 629-03-8

上下游产品

1,5-二溴戊烷 1,5-Dibromo-Pentane 111-24-0

5-溴-1-戊醇置于二乙胺基三氟化硫体系中,用 二氯甲烷 作为反应溶剂,以61%的收率获得产物1-溴-5-氟戊烷
参考文献:Itz-1,A Client-Selective Hsp90 Inhibitor,Efficiently Induces Heat Shock Factor 1 Activation
标题:Itz-1,A Client-Selective Hsp90 Inhibitor,Efficiently Induces Heat Shock Factor 1 Activation
摘要:Itz-1 Is A Chondroprotective Agent That Inhibits Interleukin-1 Beta-Induced Matrix Metalloproteinase-13 (Mmp-13) Production And Suppresses Nitric Oxide-Induced Chondrocyte Death. Here We Describe Its Mechanisms Of Action. Heat Shock Protein 90 (Hsp90) Was Identified As A Specific Itz-1-Binding Protein. Almost All Known Hsp90 Inhibitors Have Been Reported To Bind To The Hsp90 N-Terminal Atp-Binding Site And To Simultaneously Induce Degradation And Activation Of Its Multiple Client Proteins. However,Within The Hsp90 Client Proteins,Itz-1 Strongly Induces Heat Shock Factor-1 (Hsf1) Activation And Causes Mild Raf-1 Degradation,But Scarcely Induces Degradation Of A Broad Range Of Hsp90 Client Proteins By Binding To The Hsp90 C Terminus. These Results May Explain Itz-1'S Inhibition Of Mmp-13 Production,Its Cytoprotective Effect,And Its Lower Cytotoxicity. These Results Suggest That Itz-1 Is A Client-Selective Hsp90 Inhibitor.
DOI:10.1016/j.Chembiol.2009.12.012

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:EP-4281436-A1
优先权日:2021-01-20
标题 :Synthesis of polyfluorinated aryl and heteroaryl carboxamides