CAS: 4418-61-5; 5-Amino-1H-Tetrazole

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CAS号420-04-2 氰胺 | CAS号71-43-2 苯 | CAS号35038-46-1 5-azido-2H-tetrazole | CAS号104795-66-6 3-ISOPROPOXY-5-... | CAS号6154-04-7 2-甲基-5-氨基-2H-四氮唑 | CAS号5422-44-6 1-甲基-5-氨基四氮唑 | CAS号5340-04-5 1-丙基-1H-四唑-5-胺 | CAS号145181-98-2 2-propyltetrazo... | CAS号288-32-4 咪唑 | CAS号52143-97-2 4-methoxy-8-nit... | CAS号254879-86-2 3-N,6-N-bis(2H-... | CAS号25828-06-2 2-Propanone,1-(... | CAS号288-94-8 四氮唑

氰胺置于sodium Azide,碘,盐酸体系中,用 N,N-二甲基甲酰胺,水 作为反应溶剂,化学反应 6.0H,以69.2%的收率获得产物5-氨基四氮唑
参考文献:富氮咪唑,1,2,4-三唑和四唑类化合物的合成†
标题:富氮咪唑,1,2,4-三唑和四唑类化合物的合成†
摘要:制备了基于咪唑,1,2,4-三唑和四唑的分子,以用于可能在富氮气体发生器中的应用.1-(1 H-1,2,4-三唑-3-基)-1 H-四唑(9),5-(1 H-四唑-1-基)-1 H-1,2的高能盐1,2,4-三唑-3-胺(10),1-(3-叠氮基-1-ħ-1,2,4-三唑-5-基)-1 ħ四唑(11)和3-叠氮基-1 ħ-1,2,4-三唑-5-胺(12用各种阳离子部分制备).计算了它们的密度,形成热,爆炸的化学能,爆炸速度和压力.由于相应化合物分子主链的高能量贡献,所有化合物都具有很高的正形成热.考察并讨论了唑环和硝基,氨基和叠氮基对其理化性质的影响.
DOI:10.1039/c3Ra47227B

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-11434211-B2
优先权日:2020-06-16
标题:Synthesis of 5-nitrotetrazole
发明人：PIERCEY DAVIN GLENN; MANSHIP TIMOTHY D; SMITH DAWSON MICHAEL
权利人:PURDUE RESEARCH FOUNDATION
摘要:This disclosure shows the ability of a readily-available oxidizer to achieve oxidation of 5-amino-1H-tetrazole (5-AT) to 5-nitrotetrazole (5-NT) in high yields in a single pot synthesis. This strategy reduces the synthesis of this important energetic material down to a single step and eliminates highly sensitive diazonium and copper salt primary explosive intermediates. The overall yield of this process is 48-53% and the resultant aqueous solution of product effectively used for the preparation of nitrotetrazole-containing primary explosive DBX-1. Unlike current methods of nitrotetrazole preparation, the novel method is entirely solution-based and prepares a final solution of sodium nitrotetrazolate, never once needing to handle energetic intermediates or products, making it a much safer method of nitrotetrazole preparation.

专利号:US-11773112-B2
优先权日:2020-12-05
标题:Synthesis of tetrazolate salts
发明人：PRADHAN BRAJA SUNDAR; SINGH SANJEEV K; MEHTA NEHA H
权利人:PRIMODIA CHEMICALS AND PHARMACEUTICALS PRIVATE LTD
摘要:The present invention relates to a novel method of synthesis of copper (I) 5-nitrotetrazolate. Particularly, for the synthesis of the copper (I) 5-nitrotetrazolate, the present invention uses a suitable salt of 5-aminotetrazole, preferably the sulfate or the nitrate salt as the starting compound. The selection of the said starting chemical not only eliminates any safety issue arising during Sandmeyer reaction conditions to affect the functional group conversion but also greatly improves the ease of executing the synthetic protocol, rendering the process safe to be adopted for commercial manufacture of the copper (I) 5-nitrotetrazolate compound.

专利号:US-9440934-B1
优先权日:2014-04-10
标 题 :Synthesis of copper(I) 5-nitrotetrazolate
发明人：MEHTA NEHA; Oyler Karl; CHENG GARTUNG; SALAN JERRY; LENAHAN SHANNON
权利人:MEHTA NEHA; Oyler Karl; CHENG GARTUNG; SALAN JERRY; LENAHAN SHANNON; US ARMY
摘要:A method of manufacture of the primary explosive material copper(I) 5-nitrotetazolate (DBX-1) by a synthesis starting with 5-aminotetrazolate (5-AT); wherein, the synthesis provides intermediates acid copper salt of 5-NT and sodium 5-nitrotetrazolate (NaNT) sodium 5-nitrotetrazolate (NaNT)—that are both, free of any 5-aminotetrazolate (5-AT) starting material—such that the subsequent production of the DBX-1 is not inhibited. Further, this method utilizes an internal filter within the reactor—to minimize handling of explosively dangerous intermediates.

专利号:US-8835476-B2
优先权日:2005-03-04
标 题:Synthesis of novel antimicrobials
发明人：WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
权利人:WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
摘要:The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

专利号:WO-2023230307-A1
优先权日:2022-05-27
标 题 :Methods for cobinamide synthesis
发明人：BOSS GERARD; CHAN ADRIANO
权利人:UNIV CALIFORNIA
摘要:Methods of synthesis of cobinamide compounds with improved yield and purity. Methods and compositions for treating cyanide, sulfide, sodium azide, or methane-thiol exposure in a subject.