CAS: 4447-60-3; Triisopropylorthoformate

相似化合物

4285-59-0 2568-89-0 78-09-1

上下游产品

CAS号75-45-6 一氯二氟甲烷 | CAS号67-66-3 氯仿 | CAS号67-63-0 异丙醇 | CAS号149-73-5 原甲酸三甲酯 | CAS号5780-15-4 4-(Methoxymethy... | CAS号74-98-6 丙烷 | CAS号625-55-8 甲酸异丙酯 | CAS号6482-34-4 碳酸二异丙酯 | CAS号67-64-1 丙酮 | CAS号114967-51-0 2,3,4,6-四-O-苯甲基... | CAS号1132-95-2 1,1-二异丙醇缩环己酮 | CAS号349655-04-5 2,2-dimethyl-1,... | CAS号61699-62-5 方酸二异丙酯 | CAS号72931-54-5 (3,3-二异丙氧基丙基)三苯基溴化膦 | CAS号75317-09-8 2-propan-2-ylox...

异丙醚,甲酸异丙酯置于三氟化硼体系中,用 正十六烷 作为反应溶剂,化学反应 8.0H,以88%的收率获得产物原甲酸三异丙酯
参考文献:一种原羧酸酯的合成方法
标题:一种原羧酸酯的合成方法
摘要:一种原羧酸酯的合成方法,其特征在于用羧酸酯与醚在催化剂催化下在一定的温度下,一定的压力下反应一定的时间制备:

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-8981076-B2
优先权日:2008-11-29
标 题 :Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases, secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is further designed to use FMOC protecting group on various base sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides. DNA oligonucleotides containing 3′-end dA at the 3′-terminal will be produced using the FMOC-dA-supports would lead to much reduced M−1 deletion sequences, and thereby high purity.

专利号:US-8202985-B2
优先权日:2005-10-31
标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.

专利号:US-7759471-B2
优先权日:2005-10-31
标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.

专利号:US-9249175-B2
优先权日:2008-09-05
标 题 :RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays
发明人：DAMHA MASAD; LACKEY JEREMY; MITRA DEBBIE; WICKENS MARVIN; CERRINA FRANCO; SOMOZA MARK
权利人:DAMHA MASAD; LACKEY JEREMY; MITRA DEBBIE; WICKENS MARVIN; CERRINA FRANCO; AKHTAR SAIMA A; SOMOZA MARK; ROYAL INST FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY; WISCONSIN ALUMNI RES FOUND
摘要:The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.

专利号:US-3732214-A
优先权日:1970-07-16
标题 :Method for the synthesis of zeaxanthins,xanthophylls,and 3beta-carotene
发明人：SURMATIS J; WALSER A
权利人:HOFFMANN LA ROCHE
摘要:METHOD BY WHICH ZEAXANTHINS, XANTHOPYLLS AND 3-OXO-BCAROTENE CAN BE SYNTHESIZED FROM THE CONDENSATION PRODUCT OF MESITYL OXIDE AND ACETO-ACETIC ESTER AS WELL AS NEW AND NOVEL INTERMEDIATES PRODUCED IN THE SYNTHESIS. ZEAXANTHIN AND XANTHOPHYLL ARE KNOWN COLORING AGENTS FOR FOODSTUFFS, INCLUDING BEVERAGES, PHARMACEUTICAL AND COSMETIC PREPARATIONS. FURTHERMORE, THROUGH THE USE OF THE CONDENSATION PRODUCT OF MESITYL OXIDE AND ACETOACETIC ACID, NEW COMPOUNDS FOR COLORING FOODSTUFFS, INCLUDING BEVERAGES, PHARMACEUTICAL AND COSMETIC PREPARATIONS ARE PRODUCED.