Phenylmethyl (4S)-4-Methyl-6-Oxo-1,3-Oxazinane-3-Carboxylate置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 4.0H,以65%的收率获得产物l-β-高丙氨酸盐酸盐
参考文献:Diastereoselective Synthesis Of α-Methyl And α-Hydroxy-β-Amino Acids Via 4-Substituted-1,3-Oxazinan-6-Ones
标题:Diastereoselective Synthesis Of α-Methyl And α-Hydroxy-β-Amino Acids Via 4-Substituted-1,3-Oxazinan-6-Ones
摘要:1,3-Oxazinan-6-Ones Have Been Utilized In A Series Of Enolate Reactions To Produce 5-Hydroxy And 5-Alkyl-4-Substituted-1,3-Oxazinan-6-Ones With Excellent Trans Diastereoselectivity. Highlighting The Versatility Of The Oxazinanone,A Number Of Transformations Were Performed To Produce A Variety Of Protected N-H And N-Methyl Alpha-Hydroxy-And Alpha-Methyl-Beta-Amino Acids.
DOI:10.1021/jo0700326