正丙基苯置于溴,碘,铁粉体系中,化学反应生成 4-丙基溴苯 参考文献:Discotic Liquid Crystals Of Transition Metal Complexes,31: Establishment Of Mesomorphism And Thermochromism Of Bis[1,2-Bis(4-N-Alkoxyphenyl)Ethane-1,2-Dithiolene]Nickel Complexes 标题:Discotic Liquid Crystals Of Transition Metal Complexes,31: Establishment Of Mesomorphism And Thermochromism Of Bis[1,2-Bis(4-N-Alkoxyphenyl)Ethane-1,2-Dithiolene]Nickel Complexes 摘要:两系列双[1,2-双(4-正烷基苯基)乙烷-1,2-二硫醇]镍,Cn-ni(n=1-12),和双[1,2-双(4-正烷氧基苯基)乙烷-1,2-二硫醇]镍,Cno-ni(n=1-12,14,16,18)已被合成.通过使用不同的扫描量热法,偏光显微镜,温度依赖性x射线衍射技术,电子光谱和循环伏安法,研究了它们的介晶性,热变色性,超分子结构和π受体性质.从x射线衍射和电子光谱结果来看,确定了cno-ni 复合物对于 N<=10 展现两种不同颜色的盘状层状(dl)介晶相,而 Cn-ni 复合物均无介晶相,并且热变色性(棕色->绿色)归因于从 Ni-ni 键合二聚体到 Ni-s 键合二聚体的缓慢转变. DOI:10.1039/b007135H
专利号:WO-2017082924-A1 优先权日:2015-11-13 标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use 发明人:BURKE TERRENCE R JR; HYMEL DAVID 权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES 摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.
专利号:US-7470795-B2 优先权日:2004-07-27 标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides 发明人:WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA 权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT 摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
专利号:US-2009088571-A1 优先权日:2004-07-27 标题 :Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
专利号:US-7576245-B2 优先权日:2002-07-11 标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof 发明人:ZHANG WEI; LUO ZHIYONG 权利人:FLUOROUS TECHNOLOGIES INC 摘要:The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.
专利号:WO-2012024104-A2 优先权日:2010-08-16 标 题 :Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
专利号:EP-2606139-A2 优先权日:2010-08-16 标 题:Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine