专利号:US-2008183007-A1 优先权日:2004-10-08 标 题 :Process For the Preparation of Alkyl Phosphinic Acids 发明人:THELIN MATS 权利人:ASTRAZENECA AB 摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative by a radical initiated reaction. The invention also relates to compounds obtainable by the method of the invention.
专利号:US-2006159608-A1 优先权日:2004-12-03 标题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation
专利号:US-3335193-A 优先权日:1964-12-28 标 题:Synthesis of adamantane derivatives 发明人:OLAH GEORGE A 权利人:DOW CHEMICAL CO
专利号:US-2006165590-A1 优先权日:2004-12-17 标 题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled esters by photo-induced free radical carbonylation
专利号:US-7626052-B2 优先权日:2004-12-17 标 题:Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled esters by photo-induced free radical carbonylation 发明人:LANGSTROM BENGT; ITSENKO OLEKSIY; KIHLBERG TOR 权利人:GE HEALTHCARE LTD 摘要:Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
专利号:US-7667011-B2 优先权日:2004-12-03 标题:Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation 发明人:LANGSTROM BENGT; ITSENKO OLEKSIY 权利人:LANGSTROM BENGT; ITSENKO OLEKSIY 摘要:Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with water pretreated by a base are provided. The resultant carbon-isotope labeled acids are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
[参考文献]: Christopher A Paddon, Et Al. Electrosynthetic Reduction Of 1-Iodoadamantane Forming 1,1'-Biadamantane And Adamantane In Aprotic Solvents: Insonation Switches The Mechanism From Dimerisation To Exclusive Monomer Formation. Ultrason Sonochem. 2007 Jul;14(5):502-508. [参考文献]: Juan E Argüello, Et Al. Fluorescent Quenching Of The 2-Naphthoxide Anion By Aliphatic And Aromatic Halides. Mechanism And Consequences Of Electron Transfer Reactions. J Org Chem. 2003 Mar 21;68(6):2362-8. [参考文献]: Robert Vícha, Et Al. [1-(1-Adamantylamino)Ethyl-Idene]Oxonium Methane-Sulfonate. Acta Crystallogr Sect E Struct Rep Online. 2009 May 20;65(Pt 6):O1307.
合成参考文献
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