CAS: 886762-70-5; 1-Bromo-3-Fluoro-2-Nitrobenzene

该化合物是一种芳香化合物,其特点是存在一个溴原子,一个氟原子和一个附于苯环的硝基化合物;分子结构特征是位于2位置的硝基化合物(-NO2),位于1位置的溴原子和位于苯环的3位置的氟基原子,这有利于其再活动性和物理特性;该化合物通常是在室内温度下一种黄色至褐色的固体,以其在有机溶剂中的中溶性为名;该化合物由于硝基化合物的电回流性质,呈现出一种电子动力替代性替代活动,这可能影响芳基化合物的再活动.此外,卤素亚成分(溴和氟)的存在可提高其在各种化学合成和应用中的效用,包括制药和农用化学物.在处理该化合物时,应当采取安全防范措施,因为该化合物可能对其卤化和硝基功能构成健康风险.

英文名称1-Bromo-3-Fluoro-2-Nitrobenzene
中文名称2-溴-6-氟硝基苯
IUPAC名称1-bromo-3-fluoro-2-nitrobenzene
其它别名1-溴-3-氟-2-硝基苯; Benzene, 1-Bromo-3-Fluoro-2-Nitro-
CAS编号886762-70-5
MFCD编号:MFCD07368788
EINECS号:689-316-3
分子式:C6H3BrFNO2
分子量:220.0
产品CID: 1904450
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: VFPAOFBPEYCAAZ-UHFFFAOYSA-N
InChI=1S/C6H3BrFNO2/c7-4-2-1-3-5(8)6(4)9(10)11/h1-3H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi
安全声明36
危险类别码36/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2-Bromo-6-Fluoronitrobenzene 主要起始原料 Sodium Perborate And 2-Bromo-6-Fluoroaniline
65896-11-9 = 886762-70-5
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane,Water; 30 Min,Reflux1.2 Reagents: Acetic Acid,Nitric Acid,Hydrogen Peroxide Solvents: Water; 30 Min,Rt -> 90 °C
标题:Design Of Two New Chemotypes For Inhibiting The Janus Kinase 2 By Scaffold Morphing
作者:Furet,Pascal; Gerspacher,Marc; Pissot-Soldermann,Carole
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(6) 页码:1858-1860]

65896-11-9 = 886762-70-5
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: 1,2-Dichloroethane; 2 H,70 °C
标题:Effects Of Ortho-Phenyl Substitution On The Risc Rate Of D-A Type Tadf Molecules
作者:Higginbotham,Heather F.; Yi,Chih-Lun; Monkman,Andrew P.; Wong,Ken-Tsung
参考文献:Journal Of Physical Chemistry C 日期:2018 卷标:122(14) 页码:7627-7634]

65896-11-9 = 886762-70-5
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: 1,2-Dichloroethane; 2 H,70 °C
标题:Synthesis Of Pyrrolnitrin And Related Halogenated Phenylpyrroles
作者:Morrison,Matthew D.; Hanthorn,Jason J.; Pratt,Derek A.
参考文献:Organic Letters 日期:2009 卷标:11(5) 页码:1051-1054]

= 886762-70-5
反应条件:1.1 Reagents: Acetic Acid,Nitric Acid,Hydrogen Peroxide Solvents: Water; Rt; 30 Min,90 °C
标题:Discovery And Sar Of Potent,Orally Available 2,8-Diaryl-Quinoxalines As A New Class Of Jak2 Inhibitors
作者:Pissot-Soldermann,Carole; Gerspacher,Marc; Furet,Pascal; Gaul,Christoph; Holzer,Philipp; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(8) 页码:2609-2613

2-溴-6-氟苯胺置于间氯过氧苯甲酸,双氧水,硝酸体系中,用二氯甲烷,溶剂黄146 作为反应溶剂,化学反应 1.0H,反应生成 2-溴-6-氟硝基苯
参考文献:Discovery And Sar Of Potent,Orally Available 2,8-Diaryl-Quinoxalines As A New Class Of Jak2 Inhibitors
标题:Discovery And Sar Of Potent,Orally Available 2,8-Diaryl-Quinoxalines As A New Class Of Jak2 Inhibitors
摘要:We Have Designed And Synthesized A Novel Series Of 2,8-Diaryl-Quinoxalines As Janus Kinase 2 Inhibitors. Many Of The Inhibitors Show Low Nanomolar Activity Against Jak2 And Potently Suppress Proliferation Of Set-2 Cells In Vitro. In Addition,Compounds From This Series Have Favorable Rat Pharmacokinetic Properties Suitable For In Vivo Efficacy Evaluation. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2010.02.056

专利信息

专利号:US-2008280933-A1
优先权日:2006-07-25
标题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.