过氧化氢酶置于氢氧化钾,硫酸二甲酯体系中,用 乙醚,水 作为反应溶剂,以15.7 G (97%)的收率获得产物茴香酸乙酯
参考文献:2-Arylalkylthio-Imidazoles,2-Arylalkenyl-Thio-Imidazoles And 2-Arylalkinyl-Thio-Imidazoles As Anti-Inflammatory Substances And Substances Inhibiting The Release Of Cytokine
标题:2-Arylalkylthio-Imidazoles,2-Arylalkenyl-Thio-Imidazoles And 2-Arylalkinyl-Thio-Imidazoles As Anti-Inflammatory Substances And Substances Inhibiting The Release Of Cytokine
摘要:该发明涉及具有2-芳基烷硫基,2-芳基烯基硫基和2-芳基炔基硫基取代的4-杂环芳基-5-苯基咪唑衍生物,其一般式为i: 其中ar是苯基基团,Het是杂环芳基基团,A是烷基链,R1是烷硫基,烷砜基,烷砜基,磺胺基或烷基羰基基团,R2是烷基,羟基,烷氧基,烷氧羰基,磺胺基,羧基,硝基或氨基羰基基团或卤原子.n可以是1或2,M为0至2.根据该发明的化合物表现出抗炎活性.