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4-hydroxy-decan-2-one heptanal piperdinium acetate acetone (E)-2-phenyl-3-decen-2-ol Decan-2-one 3-Decen-2-on-2,4-Dinitrophenyl-hydrazon decane-2,4-dione 合成工艺路线路线简述
- 合成目标产物 3-Decen-2-One 主要起始原料 Heptaldehyde
- (文献来源)合成步骤主要原料 Heptaldehyde
2-Oxy-2-Benzyl-Decene-(3) 反应生成3-癸烯-2-酮
参考文献:Grignard; Chambret,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1926,Vol. 182,P. 302
标题:Grignard; Chambret,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1926,Vol. 182,P. 302
专利信息
专利号:US-8309742-B2
优先权日:2007-05-09
标题 :Use of the PigD protein for catalyzing 1,4-additions of 2-oxoalkanoates to α, β-unsaturated ketones
发明人:MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL
权利人:MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL; UNIV ALBERT LUDWIGS FREIBURG
摘要:The present invention relates to the preparation of compounds of the general formula II which can be obtained by 1,4 addition of 2-oxoalkanoates or 2-oxocarboxylic acids onto the appropriate ketones. The present invention also relates to the use of the PigD protein for catalysis of 1,4 additions of 2-oxoalkanoates/-carboxylic acids, for example pyruvate/pyruvic acid or 2-oxobutyrate/2-oxobutyric acid, onto aliphatic, aromatic and heterocyclic α,β-unsaturated ketones. The 1,4 additions are effected here with CO2 elimination. The use of the PigD protein as a catalyst in the aforementioned 1,4 additions enables the synthesis of addition products with stereoactive centers these addition products being preparable with an enantiomeric excess of more than 80% ee. The aliphatic, aromatic and heterocyclic α,β-unsaturated ketones which are suitable for the process are represented by the general formula I:
专利号:US-5849802-A
优先权日:1996-09-27
标题:Fungicidal spirocyclic amines
发明人:PFRENGLE WALDEMAR FRANZ AUGUST
权利人:AMERICAN CYANAMID CO
摘要:New antimicrobial spirocarbocyclic compounds are described, having the general formula I, (I) or an acid-addition salt thereof, in which R1 represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalkoxy, alkoxyalkyl, aralkyl group R2 and R3 each independently represent hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, bicycloalkyl, tricycloalkyl, alkoxyalkyl, aralkyl, aryl or haloaralkyl, a 4- to 6-membered heterocyclyl, tetrahydrofuryl or dioxolanyl group, or R2 and R3, together represents an optionally substituted, saturated or unsaturated chain which may optionally contain one or more oxygen atoms and which may optionally be aryl- or cycloalkyl-fused, and n represents zero or an integer from 1 to 3. The invention further relates to the preparation of the above spirocarbocyclic compounds, intermediates prepared during the synthesis of these compounds, compositions containing the compounds and their use as fungicides in the control of phytopathogenic fungi.
专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
专利号:WO-2020226482-A1
优先权日:2019-05-09
标题:Synergistic compositions for controlling plant pathogens with chitinolytic microorganisms / organic acid combinations and method of use thereof
发明人:LAI HONG HENG
权利人:LAI HONG HENG
摘要:The present invention relates to pesticidal compositions and methods for controlling plant pathogens, particularly basal stem rot in the oil palm primarily caused by Ganoderma species. The pesticidal compositions comprising, as active components: (A) Bioactive compound derived from a whole broth culture of an chitinolyic microorganisms, wherein the bioactive compound comprises any or any combination of: chitinolyic microorganism, whole cell broths, liquid cultures, spores, pure cultures, cell fraction, substances, suspensions, supernatants, filtrates, extract or a cell-free extract thereof or metabolite thereof or isolated compounds, wherein the bioactive compound is derived from at least one chitinolyic microorganisms that degrade chitinous substrates. The said chitinolytic microorganism is bacteria belonging to genus Bacillus, Streptomyces and/or fungal genus Trichoderma; (B) at least one organic acid; and (C) at least one pesticide selected from chemical pesticides, microbial pesticides, plant defense activators, cuticle degrading enzymes, cell wall synthesis inhibitors, bacteriocins, antifungal peptides, antimicrobial preservatives, plant oil or plant extract. More specifically, this invention envisions the use of bioactive compounds and/or metabolites from chitinolyic microorganisms in combination essentially of organic acid and the compositions comprising them, in the use form as fungicides and/or insecticides, also be present as 'booster' to other pesticides results in many cases in an expension of pesticidal spectrum of activity or in a prevention of pesticide resistance development. Furthermore, in many cases, synergistic effects are obtained. In various embodiments, the organic acid consists essentially of acetic acid, preferably acetic acid from a fermentation. The formulation is typically applied to agricultural soil or plant material. In a particular, the present invention can be used in combination with a carrier selected from the plant growth nutrient, organic fertilizer or inorganic/organic mixture fertilizer. Although the following description relates almost exclusively to managing basal stem rot (BSR) disease in oil palm primarily caused by Gonoderma species. It will be appreciated by those skill in the art that the invention could be used to treat other diseases and pests of other plants, includes but is not limited to a fungus, bacteria, actinomycete, virus, insects, Acari and/or nematodes.
专利号:CN-116997551-A
优先权日:2020-10-12
标题 :Synthesis of EGFR modulators
专利号:WO-2022077154-A1
优先权日:2020-10-12
标 题:Synthesis of egfr modulators
发明人:RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
权利人:UNIV MICHIGAN REGENTS; RECH JASON CHRISTOPHER; NYATI MUKESH K; FANG FAN; ZHANG LEI; HENSCHKE JULIAN PAUL
摘要:Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A: