3-溴-2-甲氧基-四氢呋喃置于lithium Aluminium Tetrahydride,三氯化铝体系中,化学反应 10.0H,反应生成4-甲氧基-1-丁醇 参考文献:Jonas,J.; Breinek,P.,Collection Of Czechoslovak Chemical Communications,1976,Vol. 41,P. 1188-1193 标题:Jonas,J.; Breinek,P.,Collection Of Czechoslovak Chemical Communications,1976,Vol. 41,P. 1188-1193
专利号:US-8198465-B2 优先权日:2005-10-17 标 题 :3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors 发明人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT 权利人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT; NOVARTIS AG 摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, n nor a salt thereof, and a compound of formula VIn n nor a salt thereof, wherein R 3 and R 4 as well as Act are as defined in the specification, and processes of manufacturing these.n n Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
专利号:US-4790985-A 优先权日:1986-10-16 标 题 :Synthesis of sodium aluminum hydride 发明人:NELSON GUNNER E 权利人:ETHYL CORP 摘要:In the direct synthesis process for producing NaAlH4 (pressure hydrogenation of Na and Al in a liquid phase reaction medium at an elevated temperature) advantages are realized by insuring that the initial reaction mixture contains a small amount of water and/or an alcohol. In particular, the induction period is shortened. And, the time, trouble and expense of purifying and pre-drying the reaction medium are avoided.
专利号:EP-0157887-A1 优先权日:1984-03-22 标题:Synthesis of sodium aluminum hydride 发明人:NELSON GUNNER ELWOOD 权利人:ETHYL CORP 摘要:In the direct synthesis process for producing NaAIH, (pressure hydrogenation of Na and Al in a liquid phase reaction medium at an elevated temperature) advantages are realized by insuring that the initial reaction mixture contains a small amount of water and/or an alcohol. In particular, the induction period is shortened. And, the time, trouble and expense of purifying and pre-drying the reaction medium are avoided.
专利号:US-2009088576-A1 优先权日:2006-01-30 标题:Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds 发明人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 权利人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 摘要:A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).
专利号:US-9540520-B2 优先权日:2011-08-17 标 题 :Synthesis of copper pyrithione from zinc pyrithione and copper compound 发明人:KAPPOCK PAUL S; MARTIN ROBERT J 权利人:KAPPOCK PAUL S; MARTIN ROBERT J; ARCH CHEM INC 摘要:A composition containing unique particles of copper pyrithione wherein greater than 20 wt % to 90 wt % of the particles have a particle size of greater than 10 microns, as determined by laser light scattering using a particle size distribution analyzer, and wherein the particles are flat acicular needle-shaped is described herein. Also described herein is an antifouling paint containing the copper pyrithione and a method of making the composition and antifouling paint.
专利号:US-8455655-B2 优先权日:2010-05-07 标题:Preparation of dihydropyridines 发明人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH 权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL 摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.