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上下游产品

CAS号620-13-3 3-甲基苄溴

Dl-3-甲基苯丙氨酸置于phenylalanine Ammonia-Lyase From Petroselinum Crispum体系中,用 Aq. Buffer 用作溶剂,化学反应 168.0H,以99%的收率获得
参考文献:一种来自南极假酶的新型苯丙氨酸氨裂合酶,用于非天然氨基酸的立体选择性生物转化
标题:一种来自南极假酶的新型苯丙氨酸氨裂合酶,用于非天然氨基酸的立体选择性生物转化
摘要:通过针对已知的pal序列筛选微生物基因组,鉴定了一种新型的嗜冷酵母南极假单胞菌(pza Pal)苯丙氨酸解氨酶.与真核生物的已知pal相比,Pza Pal具有显着不同的底物结合口袋,带有一个延伸的环(长26 Aa)连接到活性位点的芳香环结合区域.表征了在大肠杆菌中表达的重组pza Pal的一般性质,包括该新pal与1-苯丙氨酸(S)-1A和其他外消旋取代苯丙氨酸rac-1B-G,K的动力学特征..在大多数情况下,Pza Pal的营业额明显高于petroselinum Crispum(pc Pal)的pal.最后,在外消旋苯丙氨酸衍生物(rac-1A-S)通过酶促氨消除的动力学拆分以及对映体选择性氨加成肉桂酸衍生物(2A-S)的动力学拆分中,比较了pza Pal和pc Pal的生物催化性能..的enantiotope选择性pza Pal与ö-,米-,P-氟,ø-,P氯代和ø
Doi:10.1016/j.Cattod.2020.04.002

专利信息

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:CA-3153855-A1
优先权日:2019-10-10
标题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:EP-4041249-A1
优先权日:2019-10-10
标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:TW-202128996-A
优先权日:2019-10-10
标题:Compositions and methods for in vivo synthesis of unnatural polypeptides