CAS: 16806-93-2; 6,7-Dihydrobenzofuran-4(5H)-One

该化合物是有机化合物,其特点是双环结构,由苯环组成,与呋喃合金,这种化合物一般没有色色,可粉黄外观,以其香味,甜味和花粉芳香闻名,使其对香味和口味行业感兴趣;由于存在能够参与氢结合的呋喃功能组,该化合物具有中度极性;在标准条件下,该化合物相对稳定,但可能会发生典型的含碳基化合物反应,如核细胞添加物;该化合物在有机溶剂中的溶性一般良好,但水中的溶性有限;还研究其潜在的生物活动,包括抗微生物和抗氧化性特性,这可能有助于其在医药和天然化学中的应用.

结构式图片

相似化合物

157435-90-0 84099-58-1 50615-16-2

欧盟法规

C&L通报

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合成工艺路线路线简述

  • 合成目标产物 6,7-Dihydro-4(5H)-Benzofuranone 主要起始原料 Chloroacetaldehyde And 1,3-Cyclohexanedione
  • (文献来源)合成步骤主要原料 Chloroacetaldehyde 和 1,3-Cyclohexanedione
氯乙醛置于氢氧化钾体系中,用 甲醇,水 用作溶剂,化学反应 0.5H,以63.5%的收率获得6,7-二氢-4(5H)-苯并呋喃酮
参考文献:3-Phenoxy-4-Pyridazinol Derivative And Herbicide Composition Containing The Same
标题:3-Phenoxy-4-Pyridazinol Derivative And Herbicide Composition Containing The Same

海关参考信息

专利信息


专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人:HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人:CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-4558143-A
优先权日:1982-08-06
标 题 :Process for preparing 4-oxo-4,5,6,7-tetrahydrobenzofuran
发明人:MATSUMOTO MASAKATSU; WATANABE NOBUKO
权利人:SAGAMI CHEM RES
摘要:A 4-oxo-4,5,6,7-tetrahydrobenzofuran derivative is prepared by reacting a 1,3-cyclohexanedione derivative with chloroacetaldehyde in the presence of a base while maintaining the reaction mixture at a pH of from 4 to 10, and treating the reaction mixture with an acid. The 4-oxo-4,5,6,7-tetrahydrobenzofuran derivatives are useful as an intermediate for synthesis of various kinds of drugs.

专利号:TW-509675-B
优先权日:1997-11-13
标 题 :Method of synthesis of pyrrole amides

专利号:US-7169932-B2
优先权日:2001-06-11
标题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
发明人:KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:PFIZER
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人:KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.
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合成参考文献


参考文献:10.1055/s-0040-1719875
摘要:Pettus TRR, Chan KK. Strategies for ortho-tert-Butylation of Phenols and their Analogues. Synlett. 2022 Jan 28;33(06):575–80. doi: 10.1055/s-0040-1719875.
参考文献:10.1007/s10593-024-03361-9
摘要:Adyukov IS, Pelipko VV, Litvinov IA, Mammeri OA, Baichurin RI, Makarenko SV. Synthesis of condensed furan structures based on 1-aryl-3-bromo-3-nitropropenones. Chem Heterocycl Comp. 2024 Sep;60(9-10):442–7. doi: 10.1007/s10593-024-03361-9.
参考文献:10.1007/s00706-025-03337-1
摘要:Gomonov KA, Pelipko VV, Litvinov IA, Baichurin RI, Makarenko SV. Synthesis of new 1,2,3-thiadiazole-containing furancarboxylates. Monatsh Chem. 2025 Jun 17;156(8-9):937–42. doi: 10.1007/s00706-025-03337-1.
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