CAS: 18959-31-4; 4,5-Difluorophthalic Acid

上下游产品

CAS号942-06-3 4,5-二氯邻苯二甲酸酐 | CAS号455-86-7 3,4-二氟苯甲酸 | CAS号83506-93-8 2-氨基-4,5-二氟苯甲酸

4,5-二氯邻苯二甲酸酐置于potassium Fluoride,Sodium Hydroxide,水,盐酸体系中,用 环丁砜 用作溶剂,化学反应 24.0H,反应生成4,5-二氟邻苯二甲酸
参考文献:Indanyl-Piperazine Compounds
标题:Indanyl-Piperazine Compounds
摘要:从公式(i)中选择的化合物:其中:R3代表氢原子,R1和r2与携带它们的碳原子一起形成苯,萘或喹啉环结构,每个环结构可选择地被取代,或r1代表氢原子,R2和r3与携带它们的碳原子一起形成苯,萘或喹啉环结构,每个环结构可选择地被取代,N代表1或2,-X-代表从-(Ch2)M-O-Ak-,-(Ch2)M-Nr4-Ak-,-(Co)-Nr4-Ak-和-(Ch2)M-Nr4-(Co)-中选择的基团,M代表1到6之间的整数,Ak代表可选择地取代的烷基链,R4代表氢原子或烷基基团,Ar代表芳基或杂环芳基基团,它的对映异构体,顺反异构体和与药用酸形成的加合物.含有这些化合物的医药产品在治疗需要血清素再摄取抑制剂和/或nk1拮抗剂的病症中有用.

专利信息

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-5436368-A
优先权日:1990-10-31
标题:Intermediates in the preparation of 4,5-difluoroanthranillic acid
发明人：BRAISH TAMIM F
权利人:PFIZER
摘要:Compounds of the formula ##STR1## which are intermediates in the preparation of 4,5-difluoroanthranilic acid, an intermediate itself in the synthesis of quinolone antibacterials, and methods of preparing these intermediates.

专利号:CN-120005216-A
优先权日:2025-04-01
标题:Synthesis of fluorine functionalized metal organic framework and application of fluorine functionalized metal organic framework in adsorption of radioactive thorium

专利号:CN-111470961-A
优先权日:2020-04-14
标 题:A kind of efficient synthesis method of halogenated 1,3-indanedione compounds