CAS: 38707-70-9; Quinoline-8-Carbaldehyde

该化合物是一种多用途的七环化合物,在quinoline scarffold的8处放置,其结构使它在有机合成中成为有价值的中间体,特别是用于制备药品,农用化学品和协调综合体. 甲醛功能允许通过凝结,减少或核生殖反应进一步衍生,从而能够构建多种分子框架. 其电子缺乏的quinoline核心也有利于催化和材料科学的应用. 该复合体在标准条件下表现出高纯度和稳定性,确保合成工作流程的可靠性能. 其定义明确的再活动特征使得开发新型quinoine衍生物的研究人员更愿意选择.

结构式图片

相似化合物

86-59-9 35509-27-4 40245-26-9

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号16032-35-2 8-喹啉甲醇 | CAS号611-32-5 8-甲基喹啉 | CAS号7496-46-0 8-溴甲基喹啉 | CAS号85219-47-2 8-(二溴甲基)喹啉 | CAS号858784-66-4 N-(quinoline-8-... | CAS号615-36-1 2-溴苯胺 | CAS号16567-18-3 8-溴喹啉 | CAS号215606-70-5 8-(碘甲基)喹啉 | CAS号94127-04-5 8-氯甲基喹啉 | CAS号40245-26-9 喹啉-8-甲酸甲酯 | CAS号86-59-9 8-喹啉羧酸 | CAS号130156-58-0 1-quinolin-8-yl... | CAS号130156-62-6 2-methyl-1-quin... | CAS号130156-59-1 8-quinolinyl pe... | CAS号16032-35-2 8-喹啉甲醇 | CAS号77377-27-6 3-喹啉-8-丙烯酸 | CAS号5971-06-2 2-(quinolin-8-y... | CAS号61910-23-4 2-[2-(quinolin-... | CAS号54-01-3 4-(2-quinolin-8...

合成工艺路线路线简述

  • 合成目标产物 8-Quinolinecarbaldehyde 主要起始原料 8-Quinolinemethanol
  • (文献来源)合成步骤主要原料 8-Quinolinemethanol

海关参考信息

专利信息


专利号:US-7423154-B2
优先权日:2001-03-07
标 题 :Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates
发明人:BROWN WILLIAM; PLOBECK NIKLAS
权利人:ASTRAZENECA AB
摘要:An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral sulfinimine to give adducts in predominantly one diastereomer can subsequently be transferred into pure enantiomers of by cleavage of the chiral auxilliary which is followed by synthesis of the piperazine ring by alkylation procedures.

专利号:US-10759743-B2
优先权日:2016-10-24
标 题 :Pd-catalyzed γ-C(sp3)-H arylation / heteroarylation of free amines
发明人:YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

专利号:US-8299250-B2
优先权日:2007-10-18
标题:Chiral tridentate compounds, corresponding organometal complexes, method for preparing same and use of said compounds and complexes as ligands in asymmetrical catalysis
发明人:MAUDUIT MARC; RIX DIANE; CREVISY CHRISTOPHE; WENCEL JOANNA
权利人:MAUDUIT MARC; RIX DIANE; CREVISY CHRISTOPHE; WENCEL JOANNA; ECOLE NALE SUP ARTES METIERS; CENTRE NAT RECH SCIENT
摘要:The invention relates to a compound of the formula (I) or the formula (II) in which: W is an oxygen atom or a radical of the formula NH; X is hydrogen or an alkaline cation or a C1-C8 alkyl or a —(CH 2 ) n 3 —C(R 4 )(R 5 )(R 6 ) radical; X and R on the one hand and X and R 1 on the other hand may independently form an optionally substituted cycle with 5, 6 or 7 links. The invention also relates to complexes of said compounds with at least one metal selected from the group comprising copper, palladium, ruthenium, iridium and rhodium, and to a method for the synthesis of these compounds. These compounds and complexes can be used in various asymmetrical catalysis methods.

专利号:US-11117893-B2
优先权日:2018-09-24
标题 :Methods for preparation of substituted pyridines and related novel compounds
发明人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY
权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV
摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

专利号:US-8378099-B2
优先权日:1994-10-28
标 题:Boronic ester and acid compounds, synthesis and uses
发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

专利号:CN-107417708-A
优先权日:2017-08-04
标 题 :A kind of water-soluble copper (II) complex and its synthesis method and application
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合成参考文献


摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 430.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 196.
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