CAS: 41267-76-9; 9-Methyl-2,3,6,7-Tetrahydro-1H-Pyrano[2,3-F]Pyrido[3,2,1-Ij]Quinolin-11(5H)-One

上下游产品

CAS号1386264-02-3 8-(2,3,6,7-tetr... | CAS号41175-50-2 8-羟基久洛里定 | CAS号105-45-3 乙酰乙酸甲酯 | CAS号141-97-9 乙酰乙酸乙酯

8-(2,3,6,7-Tetrahydro-1H,5H-Benzo[ij]Quinolizine) 5-(Tert-Butoxycarbonylamino)Hex-2-Ynoate置于silver Hexafluoroantimonate,三苯基膦氯金体系中,用 1,4-二氧六环,1,2-二氯乙烷 作为反应溶剂,以90%的收率获得产物香豆素 102
参考文献:Catalytic Coupling Of Arene C-h Bonds And Alkynes For The Synthesis Of Coumarins: Substrate Scope And Application To The Development Of Neuroimaging Agents
标题:Catalytic Coupling Of Arene C-h Bonds And Alkynes For The Synthesis Of Coumarins: Substrate Scope And Application To The Development Of Neuroimaging Agents
摘要:C-H Bond Functionalization Offers Strategically Novel Approaches To Complex Organic Compounds. However,Many C-H Functionalization Reactions Suffer From Poor Compatibility With Lewis Basic Functional Groups,Especially Amines,Which Are Often Essential For Biological Activity. This Study Describes A Systematic Examination Of The Substrate Scope Of Catalytic Hydroarylation In The Context Of Complex Amino Coumarin Synthesis. The Choice Of Substrates Was Guided By The Design And Development Of The Next Generation Of Fluorescent False Neurotransmitters (Ffns),Neuroimaging Probes We Recently Introduced For Optical Imaging Of Neurotransmission In The Brain. Comparison Of Two Mild Protocols Using Catalytic Ptcl4 Or Au(Pph3)Cl/agsbf6 Revealed That Each Method Has A Broad And Mutually Complementary Substrate Scope. The Relatively Less Active Platinum System Out-Performed The Gold Catalyst With Indole Substrates Lacking Substitution At The C-3 Position And Provided Higher Regioselectivity In The Case Of Carbazole-Based Substrates. On The Other Hand,The More Active Gold Catalyst Demonstrated Excellent Functional Group Tolerance,And The Ability To Catalyze The Formation Of Strained,Helical Products. The Development Of These Two Protocols Offers Enhanced Substrate Scope And Provides Versatile Synthetic Tools Required For The Structure-Activity Examination Of Ffn Neuroimaging Probes As Well As For The Synthesis Of Complex Coumarins In General.
DOI:10.1021/jo3006842

专利信息

专利号:US-7718578-B2
优先权日:2003-03-31
标 题 :Method of synthesis and testing of combinatorial libraries using microcapsules
发明人：GRIFFITHS ANDREW DAVID; ABELL CHRIS; HOLLFELDER FLORIAN; MASTROBATTISTA ENRICO
权利人:MEDICAL RES COUNCIL
摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

专利号:US-2023366125-A1
优先权日:2003-03-31
标 题:Compartmentalised combinatorial chemistry by microfluidic control
发明人：GRIFFITHS ANDREW DAVID; WEITZ DAVID A; LINK DARREN ROY; AHN KEUNHO; BIBETTE JEROME
权利人:HARVARD COLLEGE; RES & INNOVATION UK
摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

专利号:US-9925504-B2
优先权日:2004-03-31
标 题 :Compartmentalised combinatorial chemistry by microfluidic control
发明人：GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME
权利人:GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME; HARVARD COLLEGE; MEDICAL RES COUNCIL
摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

专利号:US-2010036110-A1
优先权日:2008-08-08
标题:Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
发明人：XIE XIAOLIANG SUNNEY; SIMS PETER A; GREENLEAF WILLIAM J
权利人:XIE XIAOLIANG SUNNEY; SIMS PETER A; GREENLEAF WILLIAM J
摘要:The invention features compositions, methods, and systems for single-molecule sequencing of nucleic acids based on the continuous measurement of the incorporation of fluorogenic nucleotides in microreactors. In particular, the invention features fluorogenic compounds for use in nucleic acid sequencing. The invention provides numerous advantages over previous systems such as unambiguous determination of sequence, continuous sequencing, long read lengths, low overall cost, and ease of sample preparation.

专利号:US-2018361346-A1
优先权日:2003-03-31
标 题 :Method of synthesis and testing of cominatorial libraries using microcapsules

专利号:US-2006154298-A1
优先权日:2003-03-31
标 题:Method of synthesis and testing of combinatorial libraries using microcapsules