CAS: 4513-94-4; Pyrrole-2-Carbonitrile

相似化合物

1003-29-8 634-97-9 4551-72-8

上下游产品

CAS号1003-29-8 吡咯-2-甲醛 | CAS号32597-34-5 1H-吡咯-2-甲醛肟 | CAS号4551-72-8 1H-吡咯-2-甲酰胺 | CAS号109-97-7 吡咯 | CAS号1189-71-5 氯磺酰异氰酸酯 | CAS号1129-36-8 Cyanic acid, 4-... | CAS号74-86-2 乙炔 | CAS号16851-82-4 1-(苯磺基)吡咯 | CAS号506-68-3 溴化氰 | CAS号4551-72-8 1H-吡咯-2-甲酰胺 | CAS号89809-64-3 2-氰基-5-氯吡啶 | CAS号38180-46-0 3-氯-2-氰吡啶 | CAS号34884-10-1 N-甲基-2-吡咯腈 | CAS号918538-05-3 2,4-二氯吡咯并[2,1-f... | CAS号7782-24-3 (|S|)-(+)-2-苯丙酸 | CAS号7782-26-5 R-2-苯基丙酸 | CAS号2853-30-7 1-methyl-5-nitr... | CAS号23208-04-0 1-[(2-氨基苯基)甲基]-... | CAS号31602-66-1 5-(1H-吡咯-2-基)-2H-四唑

1H-吡咯-2-甲酰胺置于二吗啉基亚膦酰氯,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.5H,以80%的收率获得产物吡咯-2-腈
参考文献:双吗啉代磷酰氯,一种用于将伯酰胺转化为腈的新型试剂
标题:双吗啉代磷酰氯,一种用于将伯酰胺转化为腈的新型试剂
摘要:在碱存在下,双吗啉代磷酰氯(bmpc)是芳族和脂族伯酰胺的有效脱水剂,并在温和条件下以高收率和纯度提供相应的腈.在反应过程中,对映体完整性保持完整.
DOI:10.1016/j.Tetlet.2020.152747

专利信息

专利号:WO-2025078932-A1
优先权日:2023-10-09
标题 :A process for selective dimethyl carbonate (dmc) synthesis and a system thereof
发明人：PULIKKEEL UNNIKRISHNAN; ROUTRAY KAMALAKANTA; CHINTHALA PRAVEEN KUMAR; DAS ASIT KUMAR
权利人:RELIANCE INDUSTRIES LTD
摘要:The present disclosure provides a process for the selective synthesis of dimethyl carbonate 0 (DMC). More particularly, the present disclosure provides a process for inhibiting catalyst deactivation in a process for selective DMC synthesis. The process is particularly characterized by conducting the process in the presence of a small quantity of air. Further provided herein is a system for facilitating the said process. The process and the system (Figure 1) of the present disclosure prolong the life of the catalyst by virtue of introduction of air into the reactor.

专利号:WO-2025078933-A1
优先权日:2023-10-09
标题 :A process for selective dimethyl carbonate (dmc) synthesis and a system thereof
发明人：PULIKKEEL UNNIKRISHNAN; ROUTRAY KAMALAKANTA; CHINTHALA PRAVEEN KUMAR; DAS ASIT KUMAR; MANDAL SUKUMAR
权利人:RELIANCE INDUSTRIES LTD
摘要:The present disclosure provides a process for the continuous and selective synthesis of Dimethyl carbonate (DMC) addressing issues such as choking, reagent consumption and other downstream issues. The process of the present disclosure is characterized by integration of 2 reactions, one for the conversation of alcohol and carbon dioxide to DMC in the presence of a nitrile based dehydrating agent and the second for the re-generation of the nitrile based dehydrating agent in the presence of a suitable solvent. Further provided herein is a system (Figure 1) for facilitating the said process. The process is characterized by prolonged catalyst activity, efficient regeneration of reactants, low energy requirements and simple regeneration procedures.

专利号:US-6441194-B1
优先权日:1999-10-21
标 题 :Synthesis of 4-substituted pyrrole-2-carbaldehyde compounds
发明人：LIEBESKIND LANNY S; LIU WANSHENG
权利人:UNIV EMORY
摘要:The invention relates to an a process for making a 4-substituted pyrrole-2-carbaldehyde compound comprising reacting: n a. a pyrrole-2-carbaldehyde compound; and n b. an alkylating agent; n c. in the presence of at least one catalyst; to form a 4-alkyl substituted pyrrole-2-carbaldehyde compound.

专利号:US-7399870-B2
优先权日:2004-03-30
标 题 :Synthesis of pyrrole-2-carbonitriles
发明人：HELOM JEAN LOUISE; RUBEZHOV ARKADIY ZINOVIY; PILCHER ANTHONY SCOTT; WILK BOGDAN KAZIMIERZ
权利人:WYETH CORP
摘要:The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.

专利号:US-2008319204-A1
优先权日:2007-06-25
标题 :Process for the synthesis of progesterone receptor modulators
发明人：WU YANZHONG; SUTHERLAND KAREN; CONSIDINE JOHN LEO; WILK BOGDAN KAZIMIERZ; GIGUERE PIERRE; MACEWAN MICHAEL; SHARMA ARCHANA; GONTCHAROV ALEXANDER
权利人:WYETH CORP
摘要:Processes for preparing substituted oxindole-2-ones, and specifically the following, are described, wherein R 1 -R 4 , R 6 , and n are defined herein. The processes include reacting a first alkali metal hydroxide, a tetraalkyl ammonium salt, a benzonitrile, and R 6 X or XCH 2 (CH 2 ) n X′, wherein R 6 is C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 8 cycloalkyl, substituted C 3 to C 8 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic, X and X′ are, independently, leaving groups, and n is 1 to 5; (ii) reacting the product of step (i) with a second alkali metal hydroxide at a temperature of at least about 60° C.; (iii) reacting the product of step (ii) with an alkali alkoxide at a temperature of at least about 140° C. to form an oxindol-2-one; (iv) brominating the oxindol-2-one; and (v) coupling the brominated oxindol-2-one with a coupling reagent.

专利号:US-3886180-A
优先权日:1973-03-15
标 题:Process for the synthesis of N-hydroxypyrroles
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
摘要:A process is described for the preparation of N-hydroxypyrrole2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, Nhydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as antibaterials, e.g., against E. Coli.