CAS: 454-92-2; 3-(Trifluoromethyl)Benzoic Acid

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CAS号454-89-7 间三氟甲基苯甲醛 | CAS号401-78-5 间溴三氟甲苯 | CAS号201230-82-2 carbon monoxide | CAS号67-56-1 甲醇 | CAS号124-38-9 二氧化碳 | CAS号401-81-0 3-碘三氟甲苯 | CAS号2557-13-3 间三氟甲基苯甲酸甲酯 | CAS号635305-32-7 3-三氟甲基苯硼酸新戊二醇酯 | CAS号98-15-7 间氯三氟甲苯 | CAS号328-99-4 3-(三氟甲基)苯甲酰氟 | CAS号349-75-7 3-(三氟甲基)苄醇 | CAS号351-35-9 3-(三氟甲基)苯乙酸 | CAS号328-67-6 3-溴-5-三氟甲基苯甲酸 | CAS号349-76-8 间三氟甲基苯乙酮 | CAS号368-77-4 间三氟甲基苯腈 | CAS号30069-31-9 N-(3-氨基-4-甲基苯基)... | CAS号328-80-3 3-硝基-5-(三氟甲基)苯甲酸 | CAS号2557-13-3 间三氟甲基苯甲酸甲酯 | CAS号79427-88-6 2-羟基-5-三氟甲基苯甲酸

邻溴三氟甲苯置于正丁基锂,Potassium Tert-Butylate,四丁基氟化铵体系中,用 四氢呋喃,正己烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 60.75H,反应生成 3-三氟甲基苯甲酸
参考文献:三氟甲基取代的苯基硅烷:由支撑效应决定的金属化区域化学过程
标题:三氟甲基取代的苯基硅烷:由支撑效应决定的金属化区域化学过程
摘要:三乙基[(2-三氟甲基)苯基]硅烷与超碱性lic-Kor混合物反应.丁基锂和叔丁醇钾仅在 4 位("间位金属化")而不在 3 位("邻位金属化").同时含有两个三氟甲基的另外两种底物,三乙基[2,4-和2,5-双(三氟甲基)苯基]硅烷,分别在5-和4-位发生去质子化.因此,支撑效应阻止了金属化剂对任何三氟甲基的邻位的攻击,该基团在另一侧与三烷基取代基相邻.[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200500729

专利信息

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:WO-2025073833-A1
优先权日:2023-10-04
标 题:Optimized process for the preparation of iopamidol
发明人：BUONSANTI FEDERICA; MAZZON ROBERTA; FRETTA ROBERTA
权利人:BRACCO IMAGING SPA
摘要:The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of potentially hazardous reagents and solvents.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人：DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.