CAS: 455-38-9; 3-Fluorobenzoic Acid

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CAS号1041469-36-6 1-(3-fluorophen... | CAS号456-48-4 3-氟苯甲醛 | CAS号124-38-9 二氧化碳 | CAS号1121-86-4 3-氟碘苯 | CAS号1583-67-1 3-氟邻苯二甲酸 | CAS号1073-06-9 间溴氟苯 | CAS号201230-82-2 carbon monoxide | CAS号67-56-1 甲醇 | CAS号352-70-5 3-氟甲苯 | CAS号104941-39-1 4-fluorophenyl ... | CAS号491842-63-8 3-(氯甲基)-5-(3-氟苯... | CAS号320-98-9 2-硝基-5-氟苯甲酸 | CAS号456-48-4 3-氟苯甲醛 | CAS号46698-36-6 (4-CHLOROPHENYL... | CAS号33166-77-7 3-(3-氟苯基)-3-羰基丙酸乙酯 | CAS号455-37-8 间氟苯甲酰胺 | CAS号455-68-5 3-氟苯甲酸甲酯 | CAS号456-47-3 3-氟苄醇 | CAS号451-02-5 3-氟苯甲酸乙酯 | CAS号458-04-8 间氟苯乙酰氯间氟苯乙酰氯

3-氟苯酚置于锰,Bis(Triphenylphosphine)Nickel(II) Chloride,硫酰氟,新铜试剂,三乙胺体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 44.0H,反应生成 间氟苯甲酸
参考文献:使用二氧化碳的镍催化芳基和杂芳基氟代硫酸盐的羧化反应
标题:使用二氧化碳的镍催化芳基和杂芳基氟代硫酸盐的羧化反应
摘要:利用co 2作为c1合成子来构建羧酸的有效且实用的方法的开发非常重要.描述了用co 2进行镍催化的芳基氟代硫酸盐和杂芳基氟代硫酸盐的羧化,在温和条件下提供芳烃羧酸,具有非常好的产率或优异的产率.另外,开发了一种单锅酚氟代硫酸化/羧化.
DOI:10.1021/acs.Orglett.9B00836

专利信息

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人：DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.

专利号:WO-9731891-A1
优先权日:1996-03-01
标 题:Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC; LYNCH JOSEPH E; SHI YAO JUN; WELLS KENNETH M
摘要:The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-2024126692-A1
优先权日:2022-12-15
标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes
发明人：SCHOLZ HENRIK; KROKE EDWIN; KRAUSHAAR KONSTANTIN; GLATZER HOLGER JÃœRGEN; LEWIS KENRICK MARTIN; WAGNER ROLAND
权利人:MOMENTIVE PERFORMANCE MAT GMBH
摘要:The present invention is directed at a process for producing a compound of Formula (I): (R1)y(R2O)3-ySiCH2CHR3CR4R5X comprising reacting (a) an olefinic halide; (b) an alkoxysilane; (c) a catalytically effective amount of iridium-containing catalyst; and (d) a reaction-promoting effective amount of a peroxycarboxylic acid to produce the product of Formula (I).