CAS: 621-50-1; 2-(3-Nitrophenyl)Acetonitrile

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CAS号619-23-8 间硝基氯化苄 | CAS号143-33-9 氰化钠 | CAS号3958-57-4 3-硝基苄溴 | CAS号10442-39-4 氰化四丁基胺 | CAS号773837-37-9 sodium cyanide | CAS号142509-31-7 1-((methoxymeth... | CAS号121-73-3 间氯硝基苯 | CAS号1071-36-9 氰基乙酸钠 | CAS号4623-24-9 2-(3-氨基苯基)乙腈 | CAS号180079-94-1 3-[2-(B°C-氨基)乙基]苯胺 | CAS号83304-13-6 3-硝基苯基乙基胺 | CAS号1877-73-2 3-硝基苯乙酸 | CAS号25263-44-9 (3-羟苯基)乙腈 | CAS号618-98-4 间硝基苯甲酸乙酯 | CAS号52913-11-8 3-氨基苯乙酸甲酯 | CAS号621-37-4 3-羟基苯乙酸 | CAS号618-95-1 3-硝基苯甲酸甲酯 | CAS号52022-77-2 3-硝基苯乙醇

3-硝基苯乙酸置于氯化亚砜,三氯氧磷体系中,用 氯仿 作为反应溶剂,化学反应 16.0H,反应生成 3-硝基苯乙腈
参考文献: Haloethyl Urea Compounds And The Use Thereof To Attenuate,Inhibit Or Prevent Cancer Cell Migration[fr] Composes D'Uree Haloethyle Et Leur Utilisation En Vue D'Attenuer,D'Inhiber Ou De Prevenir La Migration De Cellules Cancereuses
标题: Haloethyl Urea Compounds And The Use Thereof To Attenuate,Inhibit Or Prevent Cancer Cell Migration[fr] Composes D'Uree Haloethyle Et Leur Utilisation En Vue D'Attenuer,D'Inhiber Ou De Prevenir La Migration De Cellules Cancereuses
摘要:本发明提供了如公式(I)所述的卤乙基脲化合物,并将其用作治疗剂,用于减轻,抑制或预防癌细胞迁移和癌细胞增殖.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-4499026-A
优先权日:1982-08-25
标题 :Nucleophilic substitution process
发明人：STAHLY BARBARA C; STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Nitroarylacetonitriles are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their nitriles are useful intermediates for the synthesis of pharmaceuticals.

专利号:WO-03037854-A1
优先权日:2001-10-31
标题:Method of preparing 4-chloro-3-methyl-2-butenylphenyl sulfide, di(4-chloro-3-methyl-2-butenyl)sulfide and di(4-chloro-3-methyl-2-butenyl)sulfone for synthesis of natural carotenoid products

专利号:CN-111732493-A
优先权日:2017-01-16
标题 :A kind of synthesis technique of aromatic amine compound

专利号:RU-2076108-C1
优先权日:1990-03-07
标题 :Derivatives of n-phenylglycine amide, method of their synthesis and pharmaceutical composition showing affinity to receptors of hck and gastrin

专利号:CN-111732493-B
优先权日:2017-01-16
标题:A kind of synthesis technique of aromatic amine compound