CAS: 705-21-5; 3,5-Dichlorobenzene-1-Sulfonyl Chloride

上下游产品

CAS号137897-99-5 3,3‘,5,5’-四氯二苯二硫醚 | CAS号217326-48-2 N-(3,5-二氯苯磺酰基)-l-脯氨酸 | CAS号137897-99-5 3,3‘,5,5’-四氯二苯二硫醚 | CAS号19797-32-1 3,5-二氯苯磺酰胺

3,5-二氯苯胺置于盐酸,溶剂黄146,Sodium Nitrite,二氧化硫,Copper(L) Chloride体系中,用 水 作为反应溶剂,化学反应 17.0H,反应生成 3,5-二氯苯磺酰氯
参考文献:Quinazolinone Compound And Application Thereof
标题:Quinazolinone Compound And Application Thereof
摘要:本发明涉及一系列喹唑啉酮化合物及其作为pi3Kα抑制剂的应用.具体而言,本发明涉及一种在式(i)中显示的化合物及其互变异构体或药用可接受的盐.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobu†or related reaction conditions.

专利号:US-2023128195-A1
优先权日:2017-07-06
标 题:Synthesis of halichondrins

专利号:KR-20220124279-A
优先权日:2017-07-06
标题 :Synthesis of Halicondrin

专利号:CN-118515685-A
优先权日:2017-07-06
标题 :Synthesis of halichondrin