CAS: 14216-03-6; (4As,6As,6Br,8Ar,9R,10S,12Ar,12Br,14Bs)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(Hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)-3,4,5-Trihydroxytetrahydro-2H-Py

上下游产品

CAS号17184-21-3 葳岩仙皂苷A | CAS号39524-08-8 川续断皂苷VI； 木通皂苷D | CAS号27013-91-8 α-常春藤皂苷 | CAS号33289-85-9 川续断皂苷乙 | CAS号465-99-6 常春藤皂苷元 | CAS号57539-70-5 cussonoside A | CAS号12672-45-6 葳岩仙皂苷 D

Hederagenin-3-O-α-L-Rhamnopyranosyl-(1->2)-O-α-L-Arabinopyranosyl-28-O-α-L-Rhamnopyranosyl-(1->4)-O-6-O-Acetyl-β-D-Glucopyranosyl-(1->6)-O-β-D-Glucopyranosyl Ester置于氢氧化钾体系中,化学反应 20.0H,以12 Mg的收率获得常春藤苷 C
参考文献:Studies On Nepalese Crude Drugs. Iii. On The Saponins Of Hedera Nepalensis K. Koch.
标题:Studies On Nepalese Crude Drugs. Iii. On The Saponins Of Hedera Nepalensis K. Koch.
摘要:从常春藤(hedera Nepalensis K. Koch.,五加科)的茎和树皮中分离出12种皂苷,暂时命名为hn-皂苷a(i),B(II),D1(III),D2(iv),E(v),F(vi),H(vii),I(viii),K(x),M(xii),N(xiii)和p(xiv).化合物ii,V,Xii,Xiii和xiv分别被鉴定为木通皂苷k3,K6,K10,K11和k12,这些皂苷先前已从木通(hedera Rhombea Bean)中分离得到.根据化学和物理化学证据,其他皂苷被鉴定如下:I,为菜油固醇(微量),豆固醇和β-谷固醇的β-D-葡萄糖苷混合物;Iii,常春藤苷元3-O-β-D-葡萄糖苷;Iv,齐墩果酸3-O-α-L-鼠李糖基-(1->2)-α-L-阿拉伯糖苷;Vi,3-O-α-L-阿拉伯糖基-常春藤苷元28-O-β-D-葡萄糖苷酯;Vii,常春藤苷元28-O-α-L-鼠李糖基-(1->4)-β-D-葡萄糖基-(1->6)-β-D-葡萄糖苷酯;Viii,齐墩果酸3-O-β-D-葡萄糖醛酸苷;X,常春藤苷元3-O-β-D-葡萄糖醛酸苷.化合物vi和vii虽曾分别通过部分水解木通籽皂苷d和木通皂苷k12获得,但这是它们首次从自然界中分离出来.
Doi:10.1248/cpb.33.3324

专利信息

专利号:US-9718850-B2
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis and uses thereof
发明人：GIN DAVID; ADAMS MICHELLE; DENG KAI; LIVINGSTON PHILIP; RAGUPATHI GOVINDASWAMI; CHEA ERIC; FERNANDEZ-TEJADA ALBERTO; NORDSTROEM LARS ULRIK; Walkowicz William; GARDNER JEFFREY; TAN DEREK
权利人:MEMORIAL SLOAN-KETTERING INST FOR CANCER RES
摘要:The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

专利号:CN-116445442-A
优先权日:2023-01-07
标题:UDP-glycosyltransferase and application thereof in synthesis of alpha-hederacoside glycoside compound

专利号:US-2017283450-A1
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis and uses thereof

专利号:CA-2720771-C
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis, and uses thereof

专利号:KR-102453184-B1
优先权日:2008-04-08
标 题:Triterpene saponins, methods of synthesis, and uses thereof

专利号:US-2013011421-A1
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis, and uses thereof