2,6-二甲氧基苯甲腈置于barium Dihydroxide体系中,化学反应生成2,6-二甲氧基苯甲酸 参考文献:Lobry De Bruyn,Recueil Des Travaux Chimiques Des Pays-Bas,1883,Vol. 2,P. 237 标题:Lobry De Bruyn,Recueil Des Travaux Chimiques Des Pays-Bas,1883,Vol. 2,P. 237
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:FR-2516081-A1 优先权日:1981-11-09 标 题 :SYNTHESIS OF BENZYLPYRIMIDINES AND INTERMEDIATE PRODUCTS FOR THIS SYNTHESIS
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:WO-2005113580-A1 优先权日:2004-05-21 标题 :Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis 发明人:HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III 权利人:PFIZER; HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III 摘要:The invention relates to methods of inhibiting SARS-related coronavirus viral replication activity comprising contacting a SARS-related coronavirus protease with a therapeutically effective amount of a SARS 3C like protease inhibitor of formula (I), and compositions comprising the same.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-7002020-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
[参考文献]: Gustavo Portalone, Et Al. A New Polymorph Of 2,6-Dimeth-Oxy-Benzoic Acid. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):O3394-5. [参考文献]: Jonas Lindh, Et Al. Synthesis Of Aryl Ketones By Palladium(Ii)-Catalyzed Decarboxylative Addition Of Benzoic Acids To Nitriles. Angew Chem Int Ed Engl. 2010 Oct 11;49(42):7733-7. [参考文献]: Serdar Durdagi, Et Al. Kinetic And Docking Studies Of Phenol-Based Inhibitors Of Carbonic Anhydrase Isoforms I, Ii, Ix And Xii Evidence A New Binding Mode Within The Enzyme Active Site. Bioorg Med Chem. 2011 Feb 15;19(4):1381-9.