CAS: 19064-24-5; 1,3-Difluoro-2-Nitrobenzene

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CAS号5509-65-9 2,6-二氟苯胺 | CAS号74087-85-7 二甲基二环氧乙烷 | CAS号29270-54-0 1,3-二氟-2-硝基-苯 | CAS号53981-23-0 2-氨基-3-氟苯酚 | CAS号385-01-3 3-氟-2-硝基苯酚 | CAS号196403-27-7 8-fluoro-1-oxid... | CAS号886762-86-3 6-溴-2,3-二氨基氟苯 | CAS号641-49-6 3-氟-2-硝基苯甲醚 | CAS号18645-88-0 2,3-二氨基氟苯 | CAS号1393176-28-7 (1S)-1-(4-fluor... | CAS号866082-30-6 methyl 4-(3-flu... | CAS号866082-35-1 methyl 4-(3-flu... | CAS号872141-24-7 2-(3-氟-2-硝基苯基)丙二酸二甲酯

2,6-二氟苯胺置于双氧水,硝酸,间氯过氧苯甲酸体系中,用 二氯甲烷,溶剂黄146 用作溶剂,化学反应 4.0H,反应生成2,6-二氟硝基苯
参考文献:通过乌尔曼偶联反应有效合成各种新型官能化氧代杯芳烃
标题:通过乌尔曼偶联反应有效合成各种新型官能化氧代杯芳烃
摘要:我们开发了一种有效的方法,通过从芳基二溴化物开始的 N,N-二甲基甘氨酸促进的 Ullmann 偶联反应,一步合成含有氮官能团的新型氧杂杯 [4] 芳烃,产率高达 37%.使用芳基二氟化物作为底物,可以以 25% 的收率获得大的全芳香冠醚 8.这些氧杂杯芳烃核心中氮官能团的进一步功能化可能为构建所需的分子结构和一系列氮基多齿配体提供新的机会.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2006)
Doi:10.1002/ejoc.200500879

专利信息

专利号:WO-2011106986-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.

专利号:US-2012328569-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:CN-101811973-A
优先权日:2010-04-23
标 题 :A method for the synthesis of halogenated arylamines by highly selective liquid-phase hydrogenation under solvent-free conditions

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

专利号:WO-2013153539-A1
优先权日:2012-04-13
标 题:Tricyclic compounds as tec kinase inhibitors
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; KHAIRATKAR-JOSHI NEELIMA; SHAH DAISY MANISH
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention is directed to tricyclic compounds of formula (I) as Tec kinase inhibitors, in particular ITK (interleukin-2 inducible tyrosine kinase) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by ITK.

专利号:CN-116640160-A
优先权日:2023-03-13
标题:A kind of pyrrole ring-containing boron-sulfur-doped fused-ring aromatic hydrocarbon and its synthesis method and application