CAS: 2419-94-5; Boc-Glu-Oh

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34404-28-9 1155-62-0 121343-82-6

上下游产品

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Boc-L-谷氨酸烯丙酯置于sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 0.25H,反应生成Boc-L-谷氨酸
参考文献:酯碱水解的简单方法
标题:酯碱水解的简单方法
摘要:通过使用二氯甲烷/甲醇(9:1)作用作溶剂,已经开发出一种非常温和,快速的方法,可在非水条件下有效地进行酯的碱性水解.该方法可在室温下几分钟内方便地由相应的酯和氢氧化钠提供羧酸和醇.提出了合理的反应机理.
Doi:10.1016/j.Tetlet.2007.09.074

专利信息

专利号:US-3814732-A
优先权日:1971-10-21
标 题:Modified solid supports for solid phase synthesis
发明人：WANG S
权利人:HOFFMANN LA ROCHE
摘要:SOLID SUPPORT MATERIALS USED IN THE SOLID PHASE SYNTHESIS OF COMPLEX ORGANIC MOLECULES MAY BE MODIFIED BY INTRODUCTION OF A P-OXY-BENZYL ALCOHOL OR A P-OXY-BENZYLOXYCARBONYLHYDRAZIDE LINKING GROUP TO PRODUCE MODIFIED SUPPOETS USEFUL IN SOLID PHASE PREPARATION OF PROTECTED PRODUCT FREE ACIDS AND PROTECTED PRODUCT HYDRAZIDES RESPECTIVELY. THE RESULTING PROTECTED PRODUCTS ARE PARTICULARLY USEFUL IN THE FRAGMENT CONDENSATION APPROACH TO THE SYNTHESIS OF LARGE, COMPLEX ORGANIC MOLECULES.

专利号:US-7566697-B2
优先权日:2002-06-10
标题 :Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4388235-A
优先权日:1982-02-12
标 题:Synthesis of peptides
发明人：ORLOWSKI RONALD C; SEYLER JAY K
权利人:ARMOUR PHARMA
摘要:New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

专利号:US-4217268-A
优先权日:1978-07-20
标 题:Synthesis of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
摘要:A new peptide is disclosed which has biological activity of the same type as known calcitonins and which has a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

专利号:US-12180140-B2
优先权日:2022-12-23
标 题 :Compounds and methods for liquid phase oligonucleotide synthesis
发明人：YANG GAOMAI; XIE MIN; YANG HONGRONG; WANG SHENGDONG; LAU ALDRICH N K; ZOU RUIMING; YU DAVID
权利人:HONGENE BIOTECH CORP
摘要:The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.