CAS: 394-68-3; 8-Fluoroquinoline

相似化合物

145241-75-4 16650-32-1 396-31-6

上下游产品

8-amino quinoline 2-Fluoroaniline glycerol quinoline quinoline 5,6,7,8-tetrahydroquinoline 1,2,3,4-tetrahydroisoquinoline 8-fluoro-1,2,3,4-tetrahydroquinoline

8-羟基喹啉置于硫酰氟,四甲基氟化铵体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以58%的收率获得产物8-氟喹啉
参考文献:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
标题:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
摘要:本报告描述了一种通过芳基氟磺酸 (Arofs) 中间体使用硫酰氟 (So2F2) 和四甲基氟化铵 (Nme4F) 对苯酚进行脱氧氟化的方法.我们首先证明 Arofs 与 Nme4F 的反应在温和条件下(通常在室温下)进行,以提供广泛的电子多样化和富含官能团的芳基氟化物产品.然后将该转化转化为使用 So2F2 和 Nme4F 的组合将苯酚一锅法转化为芳基氟化物.从头算计算表明,碳-氟键的形成是通过协调的过渡态而不是离散的迈森海默中间体进行的.
DOI:10.1021/jacs.6B12911

专利信息

专利号:US-2008255359-A1
优先权日:2005-09-28
标题:Novel Chemical Process For the Synthesis of Quinoline Compounds
发明人：WADE CHARLES EDWARD
权利人:WADE CHARLES EDWARD
摘要:Disclosed is a novel, simplified and economic process for making 3-phenylsulphonyl quinolines with an amine group at position 8 of the quinoline ring system, including 3-phenylsulfonyl-8-piperazin-1-yl-quinoline in particular, in the absence of a palladium catalyst. Also disclosed is the crystallization of polymorphic forms of 3-phenylsulfonyl-8-piperazin-1-yl-quinoline.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:EP-1928832-A1
优先权日:2005-09-28
标 题 :Novel chemical process for the synthesis of quinoline compounds

专利号:US-6939969-B2
优先权日:2001-04-02
标 题:Tri-and bidentate amido ligands prepared by palladium0 coupling and metallation thereof to form metal-amido catalysts
发明人：PETERS JONAS C; BROWN STEVEN D; HARKINS SETH B
权利人:CALIFORNIA INST OF TECHN
摘要:This invention provides an amido ligand and its synthesis. Use of the amide ligand in a variety of metal complexes, and transition metals in particular, is also provided.

专利号:US-3481850-A
优先权日:1967-08-01
标题 :Synthesis of fluoroarenes
发明人：PETTERSON ROBERT C; DIMAGGIO ANTHONY H
权利人:RESEARCH CORP

专利号:WO-2007039238-A1
优先权日:2005-09-28
标题 :Novel chemical process for the synthesis of quinoline compounds