CAS: 39512-49-7; 4-(4-Chlorophenyl)Piperidin-4-Ol

上下游产品

CAS号235109-63-4 1-N-B°C-4-(4-CH... | CAS号91335-13-6 4-(4-Chlorophen... | CAS号56108-25-9 1-苄基-4-(4-氯苯基)-4-哌啶醇 | CAS号193542-65-3 BX513盐酸盐 | CAS号34552-83-5 盐酸洛哌丁胺 | CAS号30005-58-4 4-(4-氯苯基)-1,2,3... | CAS号235109-63-4 1-N-B°C-4-(4-CH... | CAS号63959-33-1 4-(4-Chlorophen... | CAS号52-86-8 氟哌啶醇 | CAS号53179-11-6 洛哌丁胺 | CAS号66164-06-5 N-Didesmethyl L... | CAS号81226-60-0 (±)-3-[4-(4-Chl...

4-(4-氯苯基)哌啶置于dipotassium Peroxodisulfate,硫酸体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 4-(4-氯苯基)-4-羟基哌啶
参考文献:过硫酸钾对质子化脂肪胺的远程 C(Sp3)-h 氧化
标题:过硫酸钾对质子化脂肪胺的远程 C(Sp3)-h 氧化
摘要:这封信描述了一种使用过硫酸钾水溶液对质子化脂肪胺进行选择性远程 C(Sp 3)-h 氧化的方法的开发.质子化作用使胺底物的近端 C(Sp 3)-h 键失活,并使胺可溶于水介质.这些反应在相对温和的条件下进行(80oc下2小时内,使用胺作为限制试剂)并且不需要过渡金属催化剂.该方法适用于多种类型的 C(Sp 3)-h 键,包括伯胺,仲胺和叔胺底物中的 3°,2° 和苄基 C-h 位点.
DOI:10.1021/acs.Orglett.6B03731

专利信息

专利号:US-3714159-A
优先权日:1971-03-30
标 题:2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
发明人：JANSSEN P; NIEMEGEERS C; STOKBROEKX R; VANDENBERK J
权利人:JANSSEN PHARMACEUTICA NV
摘要:COMPOUNDS OF THE CLASS OF 2,2-DIARYL-4-(4''-ARYL-4''HYDROXY-PIPERIDINO)BUTYRAMIDES WHEREIN SAID ARYL AND SAID AMIDE FUNCTIONS ARE VARIOUSLY DEFINED GROUPS, SAID BUTURAMIDES HAVING ANTI-DIARRHEAL AND ANALGESIC ACTVITES; ALSO INCLUDED ARE NOVEL INTERMEDIATES USED IN THE SYNTHESIS OF SAID BUTYRAMIDES.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:CA-1129424-A
优先权日:1978-04-20
标题 :Synthesis of haloperidol

专利号:US-2008280933-A1
优先权日:2006-07-25
标 题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2008312271-A1
优先权日:2006-07-25
标 题 :Azabenzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-6245773-B1
优先权日:1996-05-16
标题:5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
发明人：WONG WAI C; LAGU BHARAT; NAGARATHNAM DHANAPALAN; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.