CAS: 50824-04-9; 4-Bromo-2-(Trifluoromethyl)Phenol

上下游产品

2-(trifluoromethyl)phenol 4-bromo-1-methoxy-2-(trifluoromethyl)benzene 4-bromo-phenol Langlois reagent 5-bromo-2-hydroxy-3-(trifluoromethyl)benzaldehyde 4-bromo-1-phenylmethoxy-2-(trifluoromethyl)benzene 4-(3-hydroxypropyl)-2-(trifluoromethyl)phenol 4-(benzyloxy)-3-(trifluoromethyl)benzaldehyde

4-溴-2-(三氟甲基)苯甲醚置于碳酸氢钠体系中,用 氢溴酸,溶剂黄146 作为反应溶剂,化学反应生成 4-溴-2-三氟甲基苯酚
参考文献:Alkyne Compounds With Mch Antagonistic Activity And Medicaments Comprising These Compounds
标题:Alkyne Compounds With Mch Antagonistic Activity And Medicaments Comprising These Compounds
摘要:本发明涉及一般式i的炔烃化合物 1 其中基团和残基a,B,W,X,Y,Z,R 1 和r 2 具有权利要求中给出的含义.本发明还涉及含有根据本发明至少一种炔烃的药物组合物.鉴于它们的mch受体拮抗活性,根据本发明的药物组合物适用于治疗代谢紊乱和/或进食紊乱,特别是肥胖症,暴食症,厌食症,过度进食和糖尿病.

专利信息

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.