CAS: 5220-49-5; 3-Aminocyclohex-2-Enone

该化合物是一个有机化合物,其结构独特,包括环己环和氨基组;该化合物在环己环内具有双重联系,有助于其反应和有机合成的潜在应用;氨基组(-NH2)的存在增强了其参与各种化学反应的能力,如核生殖替代和混合反应.通常,3-氨-2-环己体-1-1-1是一个无色的黄色液体或固体,视其纯度和具体条件而定.它溶于极地溶于极地溶溶剂,有利于其在各种化学过程中的使用.该化合物可能展示生物活动,使其对药用化学和药物开发具有兴趣.但是,与许多有机化合物一样,它应该谨慎处理,因为如果吸入或混合,它可能会对健康造成危害.

结构式图片

相似化合物

873-95-0 41609-04-5 54398-84-4

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合成工艺路线路线简述

  • 合成目标产物 3-Amino-2-Cyclohexen-1-One 主要起始原料 1,3-Cyclohexanedione
  • (文献来源)合成步骤主要原料 1,3-Cyclohexanedione
3-氨基苯酚置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 作为反应溶剂,60.0 °C,101.33 Kpa 条件下,反应 14.0H,以94%的收率获得产物3-氨基-2-环己烯-1-酮
参考文献:A Practical And One-Pot Procedure For The Synthesis Of 3-Amino-2-Cyclohexen-1-One From 3-Aminophenol
标题:A Practical And One-Pot Procedure For The Synthesis Of 3-Amino-2-Cyclohexen-1-One From 3-Aminophenol
摘要:A Simple,Totally Catalytic,And Environmentally Benign Process For The Synthesis Of 3-Amino-2-Cyclohexen-1-One Using 10% Pd/c-Catalyzed Hydrogenation Has Been Developed.
DOI:10.1021/op0497761

海关参考信息

专利信息


专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人:HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:US-5767131-A
优先权日:1993-04-05
标 题 :Dihydropyridines and new uses thereof
发明人:GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:The invention provides a method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the structure: ##STR1## wherein Y is --(CH 2 ) n --, where n is 1, 2, 3, 4 or 5; --(CH 2 ) h --O--(CH 2 ) k --, where h and k are independently the same or different and are 2, 3 or 4; --(CH 2 ) h --CHâ•?CH--(CH 2 ) k --; or --(CH 2 ) h --C.tbd.C--(CH 2 ) k --, where h and k are independently the same or different and are 1, 2, 3 or 4; wherein Z is O, NH, or CH 2 ; wherein R 1 is a linear or branched chain alkyl, alkoxyalkyl or arylalkyl group; wherein R 2 and R 4 are independently the same or different and are H, or a linear or branched chain alkyl group; wherein R 3 is H, a linear or branched chain alkyl, alkoxy, alkoxyalkyl or acyl group; and wherein R 5 and R 6 are independently the same or different and are H, OH, Cl, Br, F, NO 2 , CN, CF 3 , or NH 2 , or a linear or branched chain alkyl, alkoxy, alkoxycarbonyl, acyl, alkylsulfoxide, alkylsulfone, or mono- or dialkylamino group. Other active compounds containing one, two or three rings are also disclosed as well as pharmaceutical compositions prepared therefrom and methods of use in the treatment of BPH, inhibition of cholesterol synthesis, and reduction of intraocular pressue.

专利号:US-6608086-B2
优先权日:1993-04-05
标 题:Dihydropyridines and new uses thereof
发明人:GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:This invention provides dihydropyridines useful for treatment of prostatic hyperplasia, inhibition of cholesterol synthesis, and/or reduction of intraocular pressure.
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主要参考文献

[参考文献]: Atul R Gholap, Et Al. Synthesis And Evaluation Of Antifungal Properties Of A Series Of The Novel 2-Amino-5-Oxo-4-Phenyl-5,6,7,8-Tetrahydroquinoline-3-Carbonitrile And Its Analogues. Bioorg Med Chem. 2007 Nov 1;15(21):6705-15.

合成参考文献


摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 99.
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