CAS: 55289-36-6; 3-Bromo-2-Methylaniline

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CAS号55289-35-5 2-溴-6-硝基甲苯 | CAS号67866-91-5 3-bromo-2-methy... | CAS号31804-36-1 3-溴-2-甲基苯甲醚 | CAS号365427-30-1 4-溴-1-甲基-1H-吲唑 | CAS号590417-93-9 4-溴-2-甲基-2H-吲唑 | CAS号271-44-3 吲唑 | CAS号885618-33-7 1H-吲唑-4-硼酸频哪醇酯 | CAS号882678-96-8 2-甲基-3-(4,4,5,5... | CAS号861340-10-5 1H-吲唑-4-甲腈 | CAS号7766-23-6 3-溴-2-甲基苯酚 | CAS号20776-48-1 2-氨基-6-溴苯甲酸 | CAS号77603-45-3 6-溴靛红

2,6-二硝基甲苯置于ammonium Sulfide,氢溴酸,铁粉,氯化铵,Sodium Nitrite体系中,用 乙醇,水 作为反应溶剂,化学反应 5.0H,反应生成 3-溴-2-甲基苯胺
参考文献:作为 Ftsz 抑制剂的新型 4-溴-1H-吲唑衍生物的合成和抗菌活性
标题:作为 Ftsz 抑制剂的新型 4-溴-1H-吲唑衍生物的合成和抗菌活性
摘要:设计,合成了一系列作为丝状温度敏感蛋白 Z (Ftsz) 抑制剂的新型 4-溴-1H-吲唑衍生物,并测定了它们对各种表型革兰氏阳性菌和革兰氏阴性菌的体外抗菌活性.细胞分裂抑制活性.结果表明,该系列对表皮葡萄球菌和对青霉素敏感的化脓性链球菌的抗菌活性优于其他受试菌株.其中,化合物12和18对耐青霉素金黄色葡萄球菌的活性是3-甲氧基苯甲酰胺(3-Mba)的256倍和256倍,化合物18的活性是3-Mba的64倍,但4-在抑制金黄色葡萄球菌 Atcc29213 方面的活性比环丙沙星弱一倍.特别,化合物 9 对化脓性链球菌 Ps 表现出最佳活性 (4 µg/ml),分别比 3-Mba,姜黄素和环丙沙星的活性高 32 倍,32 倍和 2 倍,但为 4 倍活性低于苯唑西林钠.此外,一些合成的化合物对金黄色葡萄球菌 Atcc25923,大肠杆菌 Atcc25922 和铜绿假单胞菌 Atcc27853 的
DOI:10.1002/ardp.201400412

专利信息

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人：KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors

专利号:ES-2794012-T3
优先权日:2008-10-27
标题 :Intermediaries for the synthesis of mTOR kinase inhibitors

专利号:EP-3103803-A1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:EP-3660020-B1
优先权日:2008-10-27
标题:Process for the synthesis of mtor kinase inhibitors