CAS: 584-13-4; 4H-1,2,4-Triazol-4-Amine

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CAS号64-18-6 甲酸 | CAS号7727-37-9 氮气 | CAS号109-94-4 甲酸乙酯 | CAS号288-88-0 1,2,4-三氮唑 | CAS号1003-23-2 4-amino-1H-1,2,... | CAS号122-51-0 原甲酸三乙酯 | CAS号624-84-0 甲酰肼 | CAS号16694-46-5 甲亚胺乙酯 盐酸盐 | CAS号628-36-4 二甲酰肼 | CAS号7803-57-8 水合肼 | CAS号18998-53-3 1-(4-methoxyphe... | CAS号288-88-0 1,2,4-三氮唑 | CAS号86386-73-4 氟康唑 | CAS号86404-63-9 2,4-二氟-α-(1H-1,... | CAS号60-34-4 甲基肼 | CAS号6086-21-1 1-甲基-1,2,4-三氮唑 | CAS号13185-22-3 N-[(5-Nitro-2-f... | CAS号34948-39-5 1-(4-nitropheny... | CAS号35546-62-4 4H-1,2,4-Triazo... | CAS号32787-80-7 1-(3-nitropheny...

甲酰肼置于甲烷体系中,用 乙醇 作为反应溶剂,以68%的收率获得产物4-氨基-1,2,4-三氮唑
参考文献:一种戊环唑中间体的合成方法
标题:一种戊环唑中间体的合成方法
摘要:本发明公开了一种戊环唑中间体的合成方法,主要为2,4‑二氯苯乙酮的合成方法,2‑溴‑1‑(2,4‑二氯苯基)乙酮的合成方法和缩酮的合成方法.本发明的优点是:戊环唑新型杀菌剂的研制成功填补了国内空白,以此为基础的类似衍生物的合成研究必将方兴未艾,各种新型杀菌剂的研制成功和工业化的实施,本发明为一种新型的戊环唑合成方法.

专利信息

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-10759715-B2
优先权日:2016-02-22
标题 :Method of producing a porous crystalline material with a highly uniform structure
发明人：CHAN KWONG YU; VOSKANYAN ALBERT; LI CHI YING VANESSA
权利人:UNIV HONG KONG
摘要:Described herein is a scalable, economic, energy and time efficient method for the synthesis of a crystalline uniform nanoporous oxide material by utilizing colloidal particles in solution combustion synthesis. By removing colloids from nanocomposite via chemical etching crystalline uniform porous oxide is prepared with tailored porosity. The produced oxides have high specific surface area, high pore volume, uniform pore structure and high crystallinity. Properties of the oxide can be tuned by the concentration and size of colloids added, which affects the porous structure (mesopore diameter, pore wall thickness, surface area, and pore volume). In principle, this method can be applied to synthesize different high porosity crystalline metal oxides and nanocomposites.

专利号:US-7045635-B2
优先权日:2004-01-27
标 题:Process for the synthesis of 4-amino-4H-1,2,4-triazole
发明人：QUINLIN WILLIAM T; CATES DILLARD M
权利人:BWXT PANTEX LLC
摘要:An improved process for synthesizing 4-amino-1,2,4-triazole. Hydrazine hydrate solution is mixed into ethyl formate, ethanol, and an acidic ion exchange resin in a condenser. The solution is held at 75 degrees Celsius until no more liquid exits the condenser. The solution is then heated to between 130 and 133 degrees Celsius and kept at this temperature long enough to remove water and ethanol and to complete the synthesis. The solution is then cooled to 60 degrees Celsius and filtered to remove the ion-exchange resin. The filtered liquid is then cooled to ambient temperature.

专利号:WO-9635659-A1
优先权日:1995-05-12
标 题 :Amination of electrophilic aromatic compounds by vicarious nucleophilic substitution
发明人：MITCHELL ALEXANDER R; PAGORIA PHILLIP F; SCHMIDT ROBERT D
权利人:UNIV CALIFORNIA; MITCHELL ALEXANDER R; PAGORIA PHILLIP F; SCHMIDT ROBERT D
摘要:The present invention relates to a process to aminate electrophilic aromatic compounds by vicarious nucleophilic substitution of hydrogen using quaternary hydrazinium salts. The use of trimethylhydrazinium iodide, as well as hydroxylamine, alkoxylamines, and 4-amino-1,2,4-triazole to produce aminated aromatic structures, such as 1,3-diamino-2,4,6-trinitrobenzene (DATB), 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and 3,5-diamino-2,4,6-trinitrotoluene (DATNT), is described. DATB and TATB are useful insensitive high explosives. TATB is also used for the preparation of benzenehexamine, a starting material for the synthesis of novel materials (optical imaging devices, liquid crystals, ferromagnetic compounds).

专利号:US-8003804-B2
优先权日:2006-03-17
标题:Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; VASANT CHIKHALIKAR SANDIP
权利人:CIPLA LTD
摘要:The present invention relates to a process for the preparation of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole), substantially free from its isomeric impurity. The preparation involves reaction of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine. The present invention also relates to a process for the preparation of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile which involves: (a) the reaction of a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II; and (b) precipitation of 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent.

专利号:US-12378355-B2
优先权日:2021-11-30
标题 :Isopoly-molybdic acid coordination polymer for catalyzing ring-opening polymerization of lactide and method of manufacturing the same
发明人：HE MINGYANG; CHEN QUN; QIAN JUNFENG; ZHU YUYANG; CHEN SHENGCHUN; WEI MEIJUN
权利人:UNIV CHANGZHOU
摘要:An isopoly-molybdic acid coordination polymer and a method of manufacturing the same are provided. It relates to the field of catalysts for polylactic acid. A chemical formula of the isopoly-molybdic acid coordination polymer is [Mo2O4(μ2-OH)2(Htrz)]. Htrz is a 1,2,4-triazole ligand, and (Mo2O4)2+ is a binuclear isopoly-molybdic radical cation. (μ2-OH) is the bridging hydroxyl group. Sodium molybdate dihydrate and zinc nitrate hexahydrate undergo hydrothermal reaction in a closed condition to obtain an isopoly-molybdic acid coordination polymer that has a secondary layered structure. The synthesis of the isopoly-molybdic acid coordination polymer is simple with high yield and reproducibility. The isopoly-molybdic acid coordination polymer shows high catalytic activity towards the bulk ring-opening polymerization of lactide. The resulting polylactic acid has a weight average molecular weight exceeding 110,000. The polylactic acid has great potential in the fields of medical, degradable and packaging materials.