专利号:US-5824472-A 优先权日:1986-03-24 标 题 :Process for the synthesis of sugar nucleotides using recombinant-DNA methods 发明人:BETLACH MICHAEL R; DOHERTY DANIEL H; VANDERSLICE REBECCA W 权利人:MONSANTO CO 摘要:A recombinant-DNA mediated method for the synthesis of sugar nucleotides is disclosed. This method utilizes portable DNA sequences capable of directing the microbial synthesis of various enzymes that catalyze the synthesis of sugar nucleotides, including UDP-glucose, UDP-glucuronic acid and GDP-mannose. The sugar moieties of these sugar nucleotides may subsequently be incorporated into industrially-useful polysaccharides such as xanthan gum. It has been found that vectors containing the portable DNA sequences described herein are capable both of causing sugar nucleotide production in microorganisms previously incapable of such synthesis and of causing increased sugar nucleotide production in organisms capable of synthesizing small quantities of these compounds. In particular, plasmids pAS7, pAS9 and pTS13 are disclosed. These plasmids are capable of directing sugar nucleotide synthesis in various hosts, including Xanthomonas sp. such as X. campestris and other organisms such as E. coli and various Pseudomonas sp.
专利号:WO-2023111422-A1 优先权日:2021-12-17 标题:Electrolytic system for the synthesis of sodium perchlorate 发明人:RUMEAU NICOLAS; JEAN ALAIN; ONGARO CHRISTOPHE; GUERBERT ARNAUD; DELMAS ELSA 权利人:ARIANEGROUP SAS 摘要:The invention relates to an electrolytic system (1) for the synthesis of sodium perchlorate by electrochemical oxidation of sodium chlorate, said system comprising at least: - an electrolytic cell (3) defining a synthesis volume (V) and comprising an anode (5), which has an outer surface made of boron-doped diamond, a cathode (7), which has an outer surface made of stainless steel or graphite, and also a seal (9), which is between the anode and the cathode and defines the synthesis volume, the electrolytic cell having an inlet port (71), which is made through the cathode or the anode and is in communication with the synthesis volume, and an outlet port (73), which is made through the cathode or the anode and is in communication with the synthesis volume; - an assembly for the storage and circulation of an electrolyte, comprising: • a storage tank (10) which contains an electrolyte (12) comprising sodium chlorate and is in communication with the inlet port via an inlet pipe (14) intended for the introduction of the electrolyte into the synthesis volume, and • an outlet pipe (40) which is in communication with the outlet port intended for discharging the electrolyte from the synthesis volume; and - an electric generator connected to the anode and to the cathode.
专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-7247287-B2 优先权日:2003-06-11 标 题 :Synthesis of aluminophosphates and silicoaluminophosphates 发明人:CAO GUANG; SHAH MATU J 权利人:EXXONMOBIL CHEM PATENTS INC 摘要:The invention is directed to a method of synthesising silicoaluminophosphate and aluminophosphate molecular sieves using synthesis templates that contain at least one template of general formula R 1 R 2 N—R 3 , wherein R 1 and R 2 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and hydroxyalkyl groups having from 1 to 3 carbon atoms; R 3 is selected from the group consisting of 4- to 8-membered cycloalkyl groups, optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms, and 4- to 8-membered heterocyclic groups having from 1 to 3 heteroatoms, said heterocyclic groups being optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms and the heteroatoms in said heterocyclic groups being selected from the group consisting of O, N, and S. In particular, the present invention relates to the synthesis of silicoaluminophosphate molecular sieves of the CHA framework type having a low silicon to aluminium atomic ratio.
专利号:US-7294486-B2 优先权日:2001-09-05 标 题:Enzymatic process for the synthesis of organo-fluorine compounds 发明人:O'HAGAN DAVID; SCHAFFRATH CHRISTOPH 权利人:UNIV ST ANDREWS 摘要:There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18 F labelled fluoronucleoside compound. There is also described an enzyme derived from Streptomyces cattelya which has the capacity to catalyse the synthesis of a fluoronucleoside compound.
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
参考文献:10.1186/1757-2215-3-1 摘要:Lane D, Matte I, Rancourt C, Piché A. The prosurvival activity of ascites against TRAIL is associated with a shorter disease-free interval in patients with ovarian cancer. Journal of Ovarian Research. 2010 Jan 18;3(1):1. doi: 10.1186/1757-2215-3-1. 参考文献:10.1007/s11481-010-9192-0 摘要:Suh H, Choi S, Khattar P, Choi N, Lee SC. Histone Deacetylase Inhibitors Suppress the Expression of Inflammatory and Innate Immune Response Genes in Human Microglia and Astrocytes. Journal of Neuroimmune Pharmacology. 2010 Feb 17;5(4):521–32. doi: 10.1007/s11481-010-9192-0. 摘要:Winston AE, Charig AJ, Thong S. Mechanism of action of a desensitizing fluoride toothpaste delivering calcium and phosphate ingredients in the treatment of dental hypersensitivity. Part III: Prevention of dye penetration through dentin vs a calcium- and phosphate-free control. Compend Contin Educ Dent. 2010 Jan;31(1):46–8, 50. 参考文献:10.1016/j.jdent.2011.06.008 摘要:Lou YL, Botelho MG, Darvell BW. Reaction of silver diamine [corrected] fluoride with hydroxyapatite and protein. J Dent. 2011 Sep;39(9):612–8. doi: 10.1016/j.jdent.2011.06.008. 参考文献:10.2116/analsci.27.757 摘要:El-Shahawi MS, Bashammakh AS, Abdelmageed M. Chemical Speciation of Chromium(III) and (VI) Using Phosphonium Cation Impregnated Polyurethane Foams Prior to Their Spectrometric Determination. Analytical Sciences. 2011 Jul 10;27(7):757–63. doi: 10.2116/analsci.27.757.