CAS: 13116-27-3; (4-Iodophenyl)Hydrazine

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对碘苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应 3.0H,以78.5%的收率获得4-碘苯肼
参考文献:缺氧激活的近红外光敏剂锚定在线粒体中用于光动力治疗.
标题:缺氧激活的近红外光敏剂锚定在线粒体中用于光动力治疗.
摘要:光动力疗法被认为是一种有前途的癌症治疗方法,但仍面临一些挑战.实体瘤中的缺氧环境,肿瘤识别的不精确以及正常细胞和癌细胞之间缺乏选择性极大地阻碍了光动力疗法在临床中的应用.此外,光敏剂的"永远开启"特性也会增加正常组织在光照射下的毒性.本研究合成了一种缺氧激活的近红外光敏剂icy-N,并成功应用于体内癌症治疗.Icy-N处于失活状态,具有低荧光,而其近红外发射(λ Em = 716 Nm)是通过肿瘤部位硝基还原酶引起的还原而诱导的.此外,还原产物icy-Oh专门位于线粒体中,在660 Nm光照射下表现出高单线态氧产量,有效诱导细胞凋亡(ic 50 = 0.63 μm).在balb/c小鼠中进行的体内研究表明icy-N适用于精确的肿瘤缺氧成像,并且可以作为一种有效的光敏剂通过pdt过程抑制肿瘤生长.
Doi:10.1039/c9Sc03355F

专利信息

专利号:US-8012220-B2
优先权日:2006-04-13
标题 :Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres
发明人：DAVID HERVE; MURGUET NADEGE; GREAVES ANDREW
权利人:OREAL
摘要:The present disclosure relates to monocationic monochromophoric compounds of formula (I) and (II) and dyeing compositions and multicompartment devices comprising monocationic monochromophoric compounds of formula (I) and (II). The disclosure also relates to methods for preparing monocationic monochromophoric compounds of formula (I) and (II), and also to methods for dyeing comprising applying monocationic monochromophoric compounds of formula (I) and (II) to keratin fibers.

专利号:CN-114560814-A
优先权日:2022-03-02
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专利号:US-2009300856-A1
优先权日:2006-04-13
标题 :Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres

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优先权日:2022-03-02
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优先权日:2022-01-23
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