专利号:US-7678948-B2 优先权日:2006-06-30 标 题:Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof 发明人:THIRUVENGADAM TIRUVETTIPURAM K; WANG TAO; CHIU JOHN S; LIAO JING 权利人:SCHERING CORP 摘要:This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising:n (a) providing a substrate of Formula I containing an oxime functional group; nn n n n n n n n n n n n n n wherein R 1 and R 2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R 1 or R 2 contains a carbon/carbon double bond; and n n n (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. n n n n n nWhere R 1 and R 2 are as defined above.
专利号:US-12006291-B2 优先权日:2022-01-11 标 题 :Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid 发明人:ZHU KAICHENG; WANG TAO; ZHANG JIAJUN; CAO HUI; SHEN RUICHAO; WANG GUOQIANG; WU GEORGE G; OR YAT SUN 权利人:ENANTA PHARM INC 摘要:The present invention relates to processes for preparing a Compound (1): n nor a pharmaceutically acceptable salt or solvate thereof. Compound (1) is useful as in many pharmaceutical agents, especially is useful as key intermediate in the synthesis of certain SARS-CoV-2 3CLpro inhibitors.
专利号:US-7553987-B2 优先权日:2006-06-30 标 题:Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
专利号:US-2008009651-A1 优先权日:2006-06-30 标题:Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
专利号:CN-115073373-A 优先权日:2022-07-08 标 题:A kind of method for asymmetric synthesis of (R)-5'-methoxylabadenin
专利号:WO-2008005344-A2 优先权日:2006-06-30 标 题 :Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
摘要:Tsukamoto, M.; Kitamura, M., Science of Synthesis, (2009) 48, 352. 参考文献:10.1007/s00792-015-0796-4 摘要:Shakiba MH, Ali MS, Rahman RN, Salleh AB, Leow TC. Cloning, expression and characterization of a novel cold‑adapted GDSL family esterase from Photobacterium sp. strain J15. Extremophiles. 2016 Jan;20(1):44–55. doi: 10.1007/s00792-015-0796-4.