专利号:US-8765668-B2 优先权日:2010-06-04 标 题 :Methods of synthesis of β-aminobutyryl substituted compounds 发明人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO 权利人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO; LEK PHARMACEUTICALS 摘要:The present invention relates to process to prepare β-aminobutyryl compounds having β-amino acid core structural moieties and optionally having γ-phenyl and/or heterocyclic structural moieties. Such compounds are useful as key structure framework of modern drug chemistry.
专利号:US-5574146-A 优先权日:1994-08-30 标题:Oligonucleotide synthesis with substituted aryl carboxylic acids as activators 发明人:REDDY M PARAMESWARA; FAROOQUI FIRDOUS 权利人:BECKMAN INSTRUMENTS INC 摘要:A process for synthesizing oligonucleotides by phosphoramidite chemistry wherein the improvement is the use of substituted aryl carboxylic acids as the activators. These activators produce in situ nucleotide intermediates in which the substituted arylcarbonyl group has displaced the amidite moiety.
专利号:US-6245773-B1 优先权日:1996-05-16 标题:5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines 发明人:WONG WAI C; LAGU BHARAT; NAGARATHNAM DHANAPALAN; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES 权利人:SYNAPTIC PHARMA CORP 摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
专利号:US-6727257-B1 优先权日:1994-11-16 标题 :5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines 发明人:NAGARATHNAM DHANAPALAN; CHIU GEORGE; DHAR T G MURALI; WONG WAI C; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES; LAGU BHARAT; MIAO SHOU WU 权利人:SYNAPTIC PHARMA CORP 摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n wherein A is n which are selective antagonists for human α 1C receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotence, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1C receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
专利号:CN-105017099-A 优先权日:2015-07-15 标题 :A kind of sitagliptin chiral intermediate and asymmetric synthesis method
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合成参考文献
参考文献:10.1055/s-0033-1338535 摘要:Woydziak ZR, Fu L, Peterson BR. Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes. Synthesis (Stuttg). 2014 Jan 01;46(2):158–64.