3047-33-4 = 2893-78-9 + 87-90-1 反应条件:1.1 Reagents: Sodium Hydroxide,Chlorine Solvents: Water 标题:Simultaneous Production Of Sodium Dichloroisocyanurate And Trichloroisocyanuric Acid 参考文献:China
专利信息
专利号:US-2009198084-A1 优先权日:2006-05-02 标题:Process for the deprotection of protected amines 发明人:ALSTERS PAULUS LAMBERTUS; VERKADE JORGE MERIJN MATHIEU; QUAEDFLIEG PETER JAN LEONARD MARIO; RUTJES FLORIS PETRUS JOHANNES 权利人:ALSTERS PAULUS LAMBERTUS; VERKADE JORGE MERIJN MATHIEU; QUAEDFLIEG PETER JAN LEONARD MARIO; RUTJES FLORIS PETRUS JOHANNES 摘要:The present invention relates to a process for the deprotection of protected amine compounds, wherein the protected amine compound is contacted with an electrophilic oxidating agent that is optionally formed in situ, said electrophilic oxidating agent being selected from the group of I 2 , Br 2 , Cl 2 and compounds comprising a halogen atom having a formal oxidation state of 1+, 3+, 5+ or 7+, provided that the electrophilic oxidating agent is not iodobenzene diacetate. The process can be conveniently employed in the synthesis of 1,3-amino alcohols, β-amino acids and heterocyclic compounds, in particular β-amino acids.
专利号:US-2012095211-A1 优先权日:2010-09-22 标 题 :Substituted proline inhibitors of hepatitis c virus replication 发明人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D 权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC 摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.
专利号:US-5919992-A 优先权日:1996-06-11 标 题:Synthesis of haloalkynol 发明人:KUO DAVID L 权利人:LONZA AG 摘要:The present invention relates to process of halogenating an alkynol having 3 to 20 carbon atoms to produce a compound having the formula: R-C 3BOND (C-CH2)x-OH, wherein R is F, Cl, Br or I and x is 1 to 18. In particular, this invention provides a process for preparing a halopropynyl alcohol, specifically iodopropynyl alcohol. In one embodiment, iodopropynyl alcohol is produced by sequentially adding potassium hydroxide, potassium iodide and an oxidizing agent to a solution of propynyl alcohol at a rate and temperature sufficient to produce an iodopropynyl alcohol.
专利号:WO-2011064249-A1 优先权日:2009-11-25 标题 :Synthesis of acetoxyacetaldehyde
专利号:KR-20000016591-A 优先权日:1996-06-11 标 题:Synthesis of Haloalkinol
专利号:EP-0923519-A1 优先权日:1996-06-11 标 题:Synthesis of haloalkynol
1: Hosein I, Madeloso R, Nagaratnam W, Villamaria F, Stock E, Jinadatha C. Evaluation of a pulsed xenon ultraviolet light device for isolation room disinfection in a United Kingdom hospital. Am J Infect Control. 2016 Sep 1;44(9):e157-61. doi: 10.1016/j.ajic.2016.01.044. Epub 2016 Mar 31. 26(3):210-215. 78(8):1633-1641. doi: 10.2166/wst.2018.439.
合成参考文献
摘要:Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, -(167), 1969 摘要:National Technical Information Service., OTS0555174 摘要:Yakkyoku. Pharmacy., 31(959), 1980 摘要:Monsanto Co. Toxicity Information., -(-), 1972 摘要:IATA. Dangerous Goods Regulations. 38th ed. Montreal, Canada and Geneva, Switzerland: International Air Transport Association, Dangerous Goods Board, January, 1997., p. 136