CAS: 4892-02-8; Methyl 2-Mercaptobenzoate

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CAS号67-56-1 甲醇 | CAS号147-93-3 硫代水杨酸 | CAS号7283-41-2 Thiosalicylic acid | CAS号152766-18-2 methyl 2-(acety... | CAS号77586-85-7 4H-3,1-benzoxat... | CAS号5459-63-2 2,2'-二硫二苯甲酸二甲酯 | CAS号119-80-2 2, 2’-二硫代二苯甲酸(DTSA) | CAS号21083-36-3 8-thiabicyclo[4... | CAS号13511-92-7 S-(2-carbometho... | CAS号5651-33-2 8-oxa-10-thiabi... | CAS号57601-89-5 2-[(氰基甲基)硫代]苯甲酸甲酯 | CAS号14944-00-4 3, 4-二氢苯并[f][1,... | CAS号3704-28-7 2-(甲硫基)苯甲酸甲酯 | CAS号492-22-8 噻吨-9-酮 | CAS号199657-02-8 2-(甲基磺酰基)苯甲酸甲酯 | CAS号20054-45-9 2-巯基-N-甲基苯甲酰胺 | CAS号885949-42-8 2-(METHYLSULFAN... | CAS号4521-31-7 2-巯基苯甲醇 | CAS号2527-03-9 2-phenyl-1,2-be... | CAS号3159-07-7 二苯并[b,f][1,4]硫氮...

3,1-Benzoxathian-4-One置于劳森试剂体系中,用 Xylene 作为反应溶剂,化学反应 4.0H,反应生成 硫代水杨酸甲酯
参考文献:选定n-,O-和s-杂环的硫代物的闪蒸真空热解的研究
标题:选定n-,O-和s-杂环的硫代物的闪蒸真空热解的研究
摘要:研究了在闪蒸真空热解条件下选定的n-,O-和s-杂环的硫酮的热分解.在六元4 H-3,1-苯并沙丁胺-4-硫酮6的情况下,反应过程取决于c(2)处的取代模式(方案3).因此,该2-未取代的衍生物6A导致不稳定的产物2,该产物在用meoh处理后被定量地转化为2-巯基苯甲酸甲酯(7).对2,2-二甲基衍生物6B进行类似的热解,得到2-甲基-4 H-1-苯并噻喃-4-硫酮(8),为唯一产物.就硫邻苯二甲酸酯衍生物而言参照图15,观测到气相中的热重排以高收率产生相应的苯并[C]噻吩-1(3H)-酮16(方案6).出乎意料的是,1,3-氧硫杂环戊烷-5-酮的硫化17与劳森标准条件下的试剂导致1,2-二硫杂环丁烷衍生物19,其中,气相热解后,进行了扩环,得到3-ħ-1,2-二硫醇20(方案7).六元4 H-1,3-苯并噻嗪-4-硫酮21显示出三种产物:菲咯[9,10-C]-1,2-二硫醚(22),3
DOI:10.1002/hlca.200690104

专利信息

专利号:US-5936128-A
优先权日:1993-11-19
标题:5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
发明人：ELLSWORTH EDMUND LEE; LUNNEY ELIZABETH; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.

专利号:WO-0053577-A9
优先权日:1999-03-12
标 题:Hydrazide inhibitors of hiv-1 integrase
发明人：NEAMATI NOURI; POMMIER YVES; LIN ZHAIWEI; BURKE TERRENCE
权利人:US GOV HEALTH & HUMAN SERV; NEAMATI NOURI; POMMIER YVES; LIN ZHAIWEI; BURKE TERRENCE
摘要:The design, synthesis and antiviral activity of novel mercaptosalicylhydrazides are disclosed, which inhibit human immunodeficiency virus type-1 integrase (HIV-1 IN), an essential enzyme for effective viral replication. Examples of the compounds are N,N'-bis(2-mercaptobenzoyl)hydrazide, N,N'-bis(2,2'-dithiosalicyl)hydrazide, and N,N'-bis(2-mercaptobenzyl)-2,2'-dithiosalicylhydrazide. These compounds are effective against the integrase catalytic core domain, inhibit integrase binding to HIV LTR DNA, and inhibit integrase in preassmbled integrase-DNA complexes. The disclosed mercaptosalicylhydrazides are 300 fold less cytotoxic than other known salicylhydrazides, and exhibit antiviral activity. They are also active in Mg+2-based assays, while integrase inhibition by salicylhydrazides is strictly Mn+2-dependent. The mercaptosalicylhydrazides have no detectable effect on other retroviral targets, including reverse transcriptase, protease, and virus attachment, and exhibit no detectable activity against human topoisomerase I at concentrations that effectively inhibited integrase. The mercaptosalicylhydrazides of the invention are therefore selective inhibitors of HIV-1 integrase, are useful in therapeutic compositions for the treatment of HIV disease, and can also be used to find related antiviral drugs.

专利号:US-2007099919-A1
优先权日:2005-10-06
标题 :Composition and synthesis of new reagents for inhibition of HIV replication

专利号:US-7754773-B2
优先权日:2005-10-06
标 题:Composition and synthesis of new reagents for inhibition of HIV replication
发明人：RANA TARIQ M; STEVENSON MARIO; NATHANS ROBIN SCOTT; CAO HONG; ALI AKBAR
权利人:UNIV MASSACHUSETTS
摘要:The present invention provides compounds and compositions for inhibiting Vif and methods for treating viral infection, e.g., HIV infection.

专利号:US-8088884-B2
优先权日:2007-09-27
标 题 :Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
发明人：HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO
权利人:HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO; SERINA THERAPEUTICS INC
摘要:The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.

专利号:WO-2007044565-A2
优先权日:2005-10-06
标 题 :Composition and synthesis of new reagents for inhibition of hiv replication