CAS: 585-74-0; 1-(M-Tolyl)Ethanone

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CAS号766-82-5 间甲苯乙炔 | CAS号7287-81-2 1-(间甲苯基)乙醇 | CAS号17933-03-8 3-甲基苯硼酸 | CAS号108-24-7 乙酸酐 | CAS号100-80-1 3-甲基苯乙烯 | CAS号75-05-8 乙腈 | CAS号77344-73-1 1-(2,4-dichloro... | CAS号839721-36-7 1-(1-butoxyviny... | CAS号111-34-2 乙烯基正丁醚 | CAS号109978-08-7 1,3,5-tris[3-(b... | CAS号33166-79-9 3-间甲苯基-3-氧代丙酸乙酯 | CAS号537-92-8 N-乙酰基-3-甲苯胺 | CAS号144660-10-6 Ethanone, 2,2-d... | CAS号41908-11-6 3-乙酰苯甲醛 | CAS号6136-68-1 3-乙酰苄腈 | CAS号21886-54-4 Ethanone, 2-chl... | CAS号18826-62-5 BENZENE, 1-METH... | CAS号19355-28-3 ethyl 2-cyano-3...

3-乙基甲苯置于氧气,γ-戊内酯体系中,140.0 °C,101.33 Kpa 条件下,以69%的收率获得产物3'-甲基苯乙酮
参考文献:基于γ-戊内酯的c(Sp3)-H键氧化的简单便捷策略
标题:基于γ-戊内酯的c(Sp3)-H键氧化的简单便捷策略
摘要:C(Sp 3)-h键的有氧氧化是有机合成中的一个重要问题,氢原子转移(Hat)是引发氧化反应的有效过程.在这里,我们展示了一种基于γ-戊内酯的c(Sp 3)-h键氧化的创新策略,该策略可以由生物质生产.该反应体系促进各种苄基和烯丙基c(Sp 3)-h键和醇的有氧氧化.在 Ni 2 Al 层状双氢氧化物的帮助下,通过增加异色满 1-和 4-C-H 键之间的键解离能差异,实现了 1-异色满酮优异的化学选择性.通过药物分子的合成,甾体底物的修饰,放大的氧化实验以及从生物质中容易获得γ-戊内酯,证明了该反应系统的优异应用潜力.这项工作还报道了一种新的碳中心自由基用于激活 C(Sp 3)-h 键.
DOI:10.1039/d3Gc03639A

专利信息

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:WO-2018011378-A1
优先权日:2016-07-13
标 题 :Method for the synthesis of a polyolefin by means of romp in the presence of a ruthenium-based catalyst
发明人：PINAUD JULIEN; CHEMTOB ABRAHAM; HEROGUEZ VALÉRIE; PLACET EMELINE; SAUVANIER DAVID; LACROIX-DESMAZES PATRICK
权利人:CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS); UNIV MONTPELLIER; UNIV BORDEAUX; BORDEAUX INP; UNIV HAUTE ALSACE; AXLR SATT DU LANGUEDOC ROUSSILLON; ENSCM
摘要:The present invention relates to a method for the synthesis of a polyolefin by means of a photoinitiated ROMP reaction involving a cyclic olefin in the presence of a ruthenium-based catalyst of formula (I), in which the catalyst is generated in situ under UV radiation from an inactive ruthenium complex of formula [RuCl 2 (L)] 2 and an imidazoli(ni)um salt of formula (III).

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:WO-2011110511-A1
优先权日:2010-03-11
标题:Spect imaging agents of amyloid plaques
发明人：SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:Bayer Pharma AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X 1 , X 2 , X 3 , X 4 and X 5 are independently selected from N or C, and wherein zero or one of X 1 ( X 2 , X 3 , X 4 or X 5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X 1 ( X 2 , X 3 , X 4 or X 5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-2022145179-A1
优先权日:2020-11-12
标题 :Synthesis of aryl 1-(methoxymethyl) vinyl ketones and their use as inhibitors of mild steel corrosion
发明人：MAZUMDER MOHAMMAD ABU JAFAR; ALI SHAIKH ASROF; ODEWUNMI NURUDEEN; ALHARBI BADER; ALJEABAN NORAH; CHEN TAO; BALHARTH SALEM
权利人:SAUDI ARABIAN OIL CO; UNIV KING FAHD PET & MINERALS
摘要:Methods for preparing alkenylphenone corrosion inhibiting compositions may include providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Corrosion inhibiting compositions may include an alkenylphenone, which may be prepared by a method including providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Methods of inhibiting corrosion of a steel surface of an oilfield equipment component may include contacting the steel surface with an aqueous solution comprising a corrosion inhibitor. The corrosion inhibitor may include a composition containing an alkenylphenone prepared by reacting an arylacetone with formaldehyde in the presence of a strong base catalyst.