CAS: 608141-43-1; (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethanamine (S)-2-Acetamido-4-Methylpentanoate

该化合物是一种具有潜在药物合成和不对称催化作用的乳液衍生物,其结构将一个含乙氧基苯组与甲基硫磺基混合物结合,提高了溶性与稳定性;N-乙基-L-液基对冲改进了晶体和处理特性,使之适合精确的配方;该化合物因其定义明确的立体化学特性,在对应选择性反应方面特别有用;其坚固的磺酰基组有助于化学复原力,而芳香醚的功能可促进生物或催化系统的互动; 盐形式确保保持纯度和储物寿命,满足研发应用的严格质量要求.

英文名称(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethanamine (S)-2-Acetamido-4-Methylpentanoate
中文名称(S)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺 N-乙酰基-L-亮氨酸盐
IUPAC名称(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate
其它别名(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethanamine N-Acetyl-L-Leucine Salt; (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethylamine N-Acetyl-L-Leucine Salt; N-Acetyl-L-Leucine Compound With (Alphas)-3-Ethoxy-4-Methoxy-Alpha-[(Methylsulfonyl)Methyl]Benzenemethanamine; (2S)-2-Acetamido-4-Methylpentanoate; [(1S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]Azanium; (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethan-1-Amine Acetyl-L-Leucinate; (1S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methanesulfonyl)Ethylamine N-Acetyl L-Leucine Salt; (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethanamine (S)-2-Acetamido-4-Methylpentanoate
CAS编号608141-43-1
MFCD编号:MFCD28167941
分子式:C20H34N2O7S
分子量:446.56
产品CID: 1589290
产品分类生物化工 → 氨基酸及其衍生物 → 亮氨酸类衍生物

相似结构搜索
InChIKey: KJZXYHPZWRDLAR-JIJBYVMQSA-N
KJZXYHPZWRDLAR-UEQPJWMENA-N…
计算化学: 氢键受体数7.0氢键供体数2.0可旋转键数9.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P305+P351+P338

合成工艺路线路线简述

3-乙氧基-4-甲氧基苯甲酸甲酯置于palladium 10% On Activated Carbon,氢气,四氯化钛,Sodium Hydride,对甲苯磺酸体系中,用甲醇,正己烷,环己烷作为反应溶剂,35.0 °C,300.01 Kpa 条件下,反应 8.0H,反应生成 (S)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺 N-乙酰基-L-亮氨酸盐
参考文献:一种合成阿普斯特中间体的制备方法
标题:一种合成阿普斯特中间体的制备方法
摘要:本发明涉及一种合成阿普斯特中间体的制备方法.该方法是利用3-乙氧基-4-甲氧基-苯甲酸酯和二甲基砜在碱性条件下缩合反应反应生成2-(3-乙氧基-4-甲氧基苯)基-1-甲磺酰基乙酮(ⅱ);该化合物ⅱ与手性胺在酸性催化剂存在下反应得到1-N-取代氨基-1-(3-乙氧基-4-甲氧基)苯基-2-甲磺酰基乙烯(ⅲ),所得化合物ⅲ不经过分离直接在加氢催化剂存在下氢化,得到产品(S)-1-(3-乙氧基-4-甲氧基)苯基-2-甲基磺酰基乙胺(I),即为阿普斯特中间体,也可进一步制成n-乙酰氨基l-亮氨酸盐.本发明还提供阿普斯特的制备方法.本发明工艺流程简洁,安全环保,成本低,利于清洁的工业化生产.

海关参考信息

2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2907210001-间苯二酚
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专利信息

专利号:US-9688623-B2
优先权日:2012-02-21
标题:Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
发明人：VENKATESWARALU JASTI; RAJENDIRAN CHINNAPILLAI; REDDY NALLAMADDI RAVIKUMAR; CONNOLLY TERRENCE JOSEPH; RUCHELMAN ALEXANDER L; ECKERT JEFFREY; FRANK ANTHONY JOSEPH
权利人:CELGENE CORP
摘要:Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-Î±. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

专利号:US-9126906-B2
优先权日:2012-02-21
标题:Asymmetric synthetic processes for the preparation of aminosulfone compounds
发明人：CONNOLLY TERRENCE J; RUCHELMAN ALEXANDER L; LEONG WILLIAM W
权利人:CELGENE CORP
摘要:Processes for synthesizing aminosulfone compounds are provided. The processes provided herein utilize asymmetric reduction reactions, e.g., asymmetric hydrogenation, of protected or unprotected enamine or ketone substrates. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.

专利号:US-7427638-B2
优先权日:2002-03-20
标题 :(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:, and methods of synthesis and compositions thereof