CAS: 65915-94-8; Tert-Butyl (6-Aminohexyl)Carbamate Hydrochloride

相似化合物

51857-17-1 6055-52-3 945923-91-1

上下游产品

CAS号129392-87-6 (6-叠氮己基)氨基甲酸叔丁酯 | CAS号124-09-4 1,6-己二胺 | CAS号41840-28-2 S-B°C-2-巯基-4,6-二甲基嘧啶 | CAS号4048-33-3 6-氨基-1-己醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号75937-12-1 6-(叔丁氧羰氨基)-1-己醇 | CAS号75950-19-5 6-(tert-butoxyc... | CAS号58-85-5 D-生物素 | CAS号51857-17-1 N-B°C-1,6-二氨基己烷 | CAS号1070-19-5 Carbonazidic ac... | CAS号153162-70-0 N-B°C-6-生物素酰氨基己胺

N-(6-羟基己基)氨基甲酸叔丁酯置于palladium On Activated Charcoal,四丁基溴化铵 Sodium Azide,氯仿,氢气,三乙胺体系中,用 甲醇,水,甲苯 作为反应溶剂,60.0 °C,206.84 Kpa 条件下,反应 4.08H,反应生成 N-Boc-1,6-己二胺盐酸盐
参考文献:Mono-Protected Diamines.N α-Tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides From Amino Alcohols
标题:Mono-Protected Diamines.N α-Tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides From Amino Alcohols
摘要:N-叔丁氧羰基-α,ω-烷二胺盐酸盐3A-E是通过氨基酸醇制备,产率为66-87%.自由胺与二叔丁基二碳酸酯反应反应生成n-叔丁氧羰氨基醇1A-E.在相转移条件下通过甲磺酸酯一步转化为叠氮化物2A-E,随后在氯仿存在下进行氢解,得到目标化合物.
DOI:10.1055/s-1990-26879

专利信息

专利号:US-5977301-A
优先权日:1992-09-24
标题 :Synthesis of N-substituted oligomers
发明人：ZUCKERMAN RONALD N; KERR JANICE M; KENT STEPHEN B H; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:EP-0671928-B1
优先权日:1992-09-24
标题 :Synthesis of n-substituted oligomers
发明人：ZUCKERMANN RONALD N; KERR JANICE M; KENT STEPHEN BRIAN HENRY; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:Poly N-substituted Glycines (poly NSGs), wherein the substituents bear purine or pyrimidine bases (R<9>) every second glycine: In addition, a solid phase method for the synthesis of N-substituted oligomers of more general structures is disclosed.The poly NSGs obtainable by this method can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using the automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:US-6310180-B1
优先权日:1993-06-21
标 题 :Method for synthesis of proteins
发明人：TAM JAMES P
权利人:UNIV VANDERBILT
摘要:A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule by promoting the orthogonal coupling of the molecules to each other. In an aspect of this method, an acyl-type reaction occurs between the molecules. The method contemplates the joining of molecules of variant size to each other, as well as the coupling of multiple identical molecules. The invention also covers the ligation of unprotected peptide, proteins or nonpeptide segments to prepare therapeutic products and synthetic vaccines with linear, circularized, or branched backbone structures, as well as the site-specific modification of peptides or proteins by lipidation and pegylation.

专利号:EP-0498801-B1
优先权日:1989-09-15
标题:Solid surface for peptide synthesis
发明人：GEYSEN HENDRIK MARIO
权利人:CHIRON MIMOTOPES PTY LTD
摘要:There is disclosed a solid surface, such as the surface of a rod or pin, for use in the synthesis of polymeric compounds such as peptides. The surface comprises an active region and an inactive region being positioned such that, in use, it is below the surface of the reaction liquid in a reaction well, irrespective of minor variations in liquid levels between various wells so as to eliminate the formation of deletion compounds. There are further described such surfaces for the formation of relatively large quantities of compound wherein the active region has a higher surface area/volume ratio than that of a cylinder of corresponding volume.

专利号:US-6486350-B1
优先权日:1998-09-30
标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
发明人：AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.

专利号:EP-0789577-B1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers