CAS: 66605-57-0; Boc-Phenylalaninol

相似化合物

145149-48-0 106454-69-7 129397-83-7

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号3182-95-4 L-苯丙氨醇 | CAS号4522-04-7 N-B°C-L-phenyla... | CAS号1025839-59-1 (S)-4,6-dimetho... | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯 | CAS号13734-34-4 B°C-L-苯丙氨酸 | CAS号207122-29-0 (S)-1-叔丁基二甲基硅氧基... | CAS号72155-45-4 N-B°C-L-苯丙氨醛 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号251325-58-3 (Z)-tert-butyl ... | CAS号3182-95-4 L-苯丙氨醇 | CAS号72155-45-4 N-B°C-L-苯丙氨醛 | CAS号141403-49-8 (S)-2-叔丁氧酰胺基苯丙醇... | CAS号207122-29-0 (S)-1-叔丁基二甲基硅氧基... | CAS号29802-26-4 (2S)-N1,N1-Dime... | CAS号2323-36-6 1-[4-[2-[(4-chl... | CAS号33817-09-3 脱氧麻黄碱 | CAS号51871-62-6 (S)-3-(B°C-氨基)-... | CAS号72155-48-7 B°C-(3S,4S)-4-氨... | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯

Boc-L-苯丙氨酸置于sodium Tetrahydroborate,碳酸氢钠,Calcium Chloride体系中,用 四氢呋喃,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 10.0H,反应生成 N-Boc-L-苯丙氨醇
参考文献:设计和合成新型的基于呋喃的分子作为潜在的20S蛋白酶体抑制剂.
标题:设计和合成新型的基于呋喃的分子作为潜在的20S蛋白酶体抑制剂.
摘要:已经设计和合成了一类新型的呋喃基化合物作为潜在的20S蛋白酶体抑制剂,其中九种化合物是肽衍生物,六种分子是他汀类肽模拟物.将c末端呋喃基部分作为基于呋喃的氨基酸引入靶分子.稳定地获得了所有化合物,产率中等至高.化合物12是选择性的中度有效的蛋白酶体拟肽抑制剂.它有效地抑制了hepg2和hl-60的增殖.
DOI:10.1016/j.Bmcl.2006.11.020

专利信息

专利号:US-6358928-B1
优先权日:1999-11-22
标 题 :Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
发明人：RASNICK DAVID W
权利人:ENZYME SYSTEMS PRODUCTS
摘要:Novel alpha-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing alpha-amino and peptidyl sulfonyl imidazolides and their use in the treatment of disease states characterized by an over-activity of serine proteases are also disclosed. Novel synthetic methods for the synthesis of sulfonyl derivatives, particularly alpha-amino and peptidyl sulfonyl derivatives, from thioic acid S-esters are also disclosed.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:EP-1144360-B1
优先权日:1999-01-22
标题 :A method for the synthesis of compounds of formula 1 and derivatives thereof

专利号:CN-117623988-A
优先权日:2022-08-17
标题 :A kind of synthesis method of N-Boc-L-phenylalanin aldehyde

专利号:CN-116730873-A
优先权日:2022-03-02
标 题 :A kind of synthesis method of N-Boc-L-phenylalanin aldehyde