CAS: 707-37-9; 1-Hydroxy-3,5-Dimethyladamantane

上下游产品

CAS号702-79-4 1,3-二甲基金刚烷 | CAS号941-37-7 1-溴-3,5-二甲基金刚烷 | CAS号101821-77-6 3,5-dimethylada... | CAS号76-05-1 三氟乙酸(TFA) | CAS号56696-00-5 1,5-dimethyl-7-... | CAS号77287-34-4 甲亚胺酸 | CAS号19982-07-1 N-乙酰基-3,5-二甲基-1-金刚烷胺 | CAS号41100-52-1 盐酸美金刚 | CAS号351329-88-9 1-甲酰氨基-3,5-二甲基金刚烷 | CAS号941-37-7 1-溴-3,5-二甲基金刚烷 | CAS号707-36-8 1-氯-3,5-二甲基金刚烷 | CAS号702-79-4 1,3-二甲基金刚烷 | CAS号33670-21-2 5,7-Dimethyl-2-... | CAS号33794-98-8 1,5-Dimethyl-2-... | CAS号14202-14-3 3,5-二甲基-1-金刚烷乙酸 | CAS号17768-32-0 Tricyclo[3.3.1.... | CAS号19982-07-1 N-乙酰基-3,5-二甲基-1-金刚烷胺

3,5-二甲基-1,7-二溴金刚烷置于platinum(Iv) Oxide Sodium Hydroxide,水,氢气体系中,用 1,4-二氧六环,溶剂黄146 作为反应溶剂,化学反应 27.0H,反应生成 3,5-二甲基-1-金刚烷醇
参考文献:3-氨基-3-甲基二环[3.3.1]壬烷的合成:远藤-选择性在1,3,5,7α-Tetramethylbicyclo [3.3.1]壬烷-3-醇的ritter反应
标题:3-氨基-3-甲基二环[3.3.1]壬烷的合成:远藤-选择性在1,3,5,7α-Tetramethylbicyclo [3.3.1]壬烷-3-醇的ritter反应
摘要:由相应的酮2A和2B制备1,3,5,7α-和1,3,5,7β-四甲基双环[3.3.1]壬南-3-醇3A和3B.7α甲基异构体3A中选择性地得到内型-3α-ñ与氰化三甲基硅烷的ritter反应-Formylaminobicyclononane 10.在相同反应条件下,7β-甲基差向异构体3B遇水消除,反应生成双环[3.3.1] Non-2-Ene 12.所述内酰胺结构通过x-射线分析证实..
DOI:10.1039/a904394B

专利信息

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:CN-102942490-A
优先权日:2012-12-02
标题:Synthesis of Memantine Hydrochloride

专利号:CN-108218720-A
优先权日:2018-01-16
标 题 :A kind of synthesis process improvement method of memantine hydrochloride