CAS: 74181-34-3; 2,2-Dimethyl-1,3-Dioxan-5-One

相似化合物

3391-30-8 4728-12-5 15186-48-8

上下游产品

1,5-Dioxaspiro[5.5]Undecan-3-One 158632-48-5
1,3-Dioxan-5-One 87683-81-6
4,4-二甲基-3,5-二噁环己醇 2,2-Dimethyl-[1,3]Dioxan-5-Ol 3391-30-8

4,4-二甲基-3,5-二噁环己醇置于chromium(Vi) Oxide体系中,用 水,甲苯 作为反应溶剂,以40%的收率获得产物2,2-二甲基-1,3-二恶烷-5-酮
参考文献:一种5-脂氧合酶激活蛋白活性抑制剂及其制备方法
标题:一种5-脂氧合酶激活蛋白活性抑制剂及其制备方法
摘要:本发明公开了一种5‑脂氧合酶激活蛋白活性抑制剂及其制备方法,所述抑制剂的结构式为式中r1,R2各自独立的代表c1~c6烷基;r3代表cmh2M+1,M=1~18的整数;r4代表h,Oh,C1~c6烷基,C1~c4烷氧基,卤素或三氟甲基;n=1或2.本发明抑制剂是以2,2‑二烷基‑1,3‑二噁烷‑5‑醇类化合物为起始原料,依次经三氧化铬氧化,格氏反应,Appel溴取代,胺代反应制备而成,合成路线短,收率高,环境友好,原料来源广,成本低,活性好,可行性高.

专利信息

专利号:WO-2009026961-A1
优先权日:2007-08-30
标 题:Processes for the preparation of pancratistatin and pancratistatin analogues
发明人：ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
权利人:UNIV SANTIAGO COMPOSTELA; ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
摘要:Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a chiral amine is used. Reduction processes then give new and advanced intermediates that are useful for the preparation of pancratistatin or selected pancratistatin analogues. The reported process also provides a method for the efficient synthesis of nitroenals, starting materials of the synthesis. Analogues of pancratistatin are also provided.

专利号:US-7968734-B2
优先权日:2004-07-01
标 题 :Organocatalysts and methods of use in chemical synthesis
发明人：WANG WEI; WANG JIAN; LI HAO
权利人:STC UNM
摘要:The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.

专利号:EP-3041832-A1
优先权日:2013-09-06
标题 :Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib

专利号:CA-2922210-A1
优先权日:2013-09-06
标题 :Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib

专利号:US-2016194354-A1
优先权日:2013-09-06
标 题 :Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib
发明人：HÖFERL-PRANTZ KATHRIN; WILHELM THORSTEN
权利人:SANDOZ AG
摘要:It is provided an improved process for preparing Carfilzomib, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib.

专利号:WO-2015032622-A1
优先权日:2013-09-06
标题 :Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib