CAS: 75344-77-3; 4-Bromo-3,5-Dimethylbenzonitrile

上下游产品

CAS号557-21-1 氰化锌 | CAS号864825-79-6 4-Bromo-3,5-dim... | CAS号400822-49-3 4-bromo-3,5-dim... | CAS号400822-47-1 4-溴-3,5-二甲基苯甲醛 | CAS号864825-81-0 4-溴-3, 5-二甲基-苯甲酰胺 | CAS号7697-32-7 4-Bromo-3,5-... | CAS号100189-84-2 2,5-二溴间二甲苯

2-Bromo-5-(Bromomethyl)-1,3-Dimethylbenzene置于ammonium Hydroxide,碘体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以73.5%的收率获得产物3,5-二甲基-4-溴苯腈
参考文献:一种艾沙度林中间体的制备方法
标题:一种艾沙度林中间体的制备方法
摘要:本发明公开了一种艾沙度林中间体的制备方法,该中间体的结构对应于式ⅳ,该方法包括使用式ⅰ的2‑卤代‑均三甲苯作为原料,经溴代,氰基化共2步反应,最终得到式ⅳ的中间体.本发明中合成方法原料便宜易得,成本低廉,便于生产放大;同时反应条件温和,安全系数较高,收率较高.

专利信息

专利号:US-9187408-B2
优先权日:2008-10-27
标 题 :Process for the preparation of protected L-alanine derivatives
发明人：ANZALONE LUIGI; FEIBUSH PENINA; VILLANI FRANK J
权利人:JANSSEN PHARMACEUTICA NV; JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

专利号:US-9308194-B2
优先权日:2013-11-28
标 题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：LINGARD IAIN; HAMPRECHT DIETER
权利人:BOEHRINGER INGELHEIM INT
摘要:A compound of formula I, n nwherein the groups R 1 , R 2 , R 3 , X, m, and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.