专利号:US-6395894-B2 优先权日:1998-04-16 标 题 :Process for the synthesis of carbapenem intermidiates, and compounds produced 发明人:PYE PHILIP J; REIDER PAUL J; ROSSEN KAI; VOLANTE RALPH P 摘要:A process of synthesizing a compound of structural formula 6is disclosed wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents a benzyl, C1-6 alkyl or aryl; Y represents C1-3 alkyl, O, NH or S; X represents O, NH, or S and R5 represents a carboxy protecting group, comprising reacting a compound of formula 5:wherein R1, R2, R5, X and Y are as previously described with a phosphite or phosphonite reagent to produce a compound of formula 6. Further disclosed is an efficient method for the synthesis of a compound of formula 2:which comprises reacting a 4-acyl-2-azetidinone with a titanium, zirconium or hafnium enolate of a 1-hydroxy-2-butanone derivative.
专利号:US-7070757-B2 优先权日:2000-10-02 标 题:Method for producing catalysts consisting of metal of the platinum group by means of electroless deposition and the use thereof for the direct synthesis of hydrogen peroxide 发明人:FISCHER MARTIN; BUTZ THOMAS 权利人:BASF AG 摘要:Catalysts produced by electroless deposition of at least one platinum metal on a nonporous nonmetallic support can be used for the synthesis of hydrogen peroxide from the elements and for the hydrogenation of organic compounds.
专利号:US-2001047100-A1 优先权日:2000-04-26 标 题:Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives 发明人:KJAERSGAARD HANS JOERGEN; PHILLIPS JIM; ALI SYED M 摘要:Novel intermediates useful in the preparation of optically active H 3 histamine receptor antagonist 2-(4-imidazoyl)-cyclopropyl derivatives are disclosed.
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-6194568-B1 优先权日:1998-07-13 标题:Process for synthesizing carbapenem intermediates 发明人:JENSEN MARK S; XIAO YI; YANG CHUNHUA; WELLS KENNETH M; YASUDA NOBUYOSHI 权利人:MERCK & CO INC 摘要:The invention describes an improved process for synthesizing 1-beta-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention.The invention relates to the synthesis of a compound of formula 3:wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein.
专利号:US-2014243404-A1 优先权日:2010-09-14 标题 :Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby 发明人:SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P 权利人:SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P; UNIV COLUMBIA 摘要:This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is:
摘要:Toxicology and Applied Pharmacology., 3(689), 1961 [] 摘要:Hawley, G.G. The Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand Reinhold Co., 1977., p. 711