CAS: 878671-94-4; 4-Cyclopropylnaphthalen-1-Amine

该化合物是一种有机化合物,其特点是以一个矿类和环丙基组替代了氯化萘脊柱,并具有一个环丙丙烯-1-胺基.该矿功能组的存在表明,它可以参与氢结扎,这可能影响其溶性与再活性.环丙基组是一个由三名成员组成的环,引进了独特的消毒和电子特性,可能影响化合物的总体稳定性和再活性.该化合物可能由于氯化萘结构(主要是非极性结构)而表现出疏水性的特点.此外,该矿的存在可能具有基本性,使其与酸相互作用形成盐.其潜在应用可能跨越各个领域,包括制药和材料科学,其中替代的氯化萘可作为中间或活性药物成分.然而,熔点,沸点和再活性等具体特性将需要精确定性的经验数据.

英文名称4-Cyclopropylnaphthalen-1-Amine
中文名称4-环丙基-1-氨基萘
IUPAC名称4-cyclopropylnaphthalen-1-amine
其它别名4-环丙基-1-氨基萘; 1-萘胺-4-环丙烷; 4-Cyclopropyl-1-Naphthalenamine
CAS编号878671-94-4
MFCD编号:MFCD11109543
分子式:C13H13N
分子量:183.25
产品CID: 1887554
产品分类有机原料→分子砌块→芳环类化合物→萘类化合物

相似结构搜索
InChIKey: NYKSBMRQNSCVMO-UHFFFAOYSA-N
InChI=1S/C13H13N/c14-13-8-7-10(9-5-6-9)11-3-1-2-4-12(11)13/h1-4,7-9H,5-6,14H2…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

相似化合物

1533519-92-4 1533519-87-7 1533519-91-3

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

CAS号878671-93-3 1-Cyclopropyl-4... | CAS号2298-07-9 1-氨基-4-溴萘 | CAS号411235-57-9 环丙基硼酸 | CAS号25033-19-6 1-环丙基萘 | CAS号90-11-9 1-溴代萘

合成工艺路线路线简述

23719-80-4 + 90-11-9 = 878671-94-4
反应条件:1.1 Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Tetrahydrofuran2.1 Reagents: Sodium Nitrite; 0 °C3.1 Reagents: Hydrogen Catalysts: Palladium
标题:The Development Of An Effective Synthetic Route Of Lesinurad (Rdea594)
作者:Meng,Qing; Et Al
参考文献:Chemistry Central Journal 日期:2017 卷标:11]

411235-57-9 + 2298-07-9 = 878671-94-4
反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Toluene,Water; 6 H,90 °C
标题:Arylazolyl(Azinyl)Thioacetanilides: Part 19: Discovery Of Novel Substituted Imidazo[4,5-B]Pyridin-2-Ylthioacetanilides As Potent Hiv Nnrtis Via A Structure-Based Bioisosterism Approach
作者:Li,Xiao; Et Al
参考文献:Chemical Biology & Drug Design 日期:2016 卷标:88(2) 页码:241-253

1-溴代萘置于1,3-Bis[(Diphenylphosphino)Propane]Dichloronickel(II),硝酸,氯化铵,溶剂黄146,锌体系中,用四氢呋喃,水作为反应溶剂,化学反应 61.0H,反应生成 4-环丙基-1-萘胺
参考文献:Lesinurad类似物及其制备方法和医药用途
标题:Lesinurad类似物及其制备方法和医药用途
摘要:本发明涉及一种通式(i)所示的一种lesinurad类似物,其制备方法以及含有该衍生物的药物组合物,以及其作为治疗剂特别是作为高尿酸血症和痛风药物中的用途,其中通式(i)中的各取代基的定义与说明书中的定义相同.

海关参考信息

2902600000-乙苯
2902700000-异丙基苯
2902902000-精萘
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9296709-B2
优先权日:2012-07-03
标题 :Manufacture of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid
发明人：GUNIC ESMIR; GALVIN GABRIEL
权利人:ARDEA BIOSCIENCES INC
摘要:Described herein are certain processes for the synthesis of compounds of Formula (I):

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÃ‰REZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:EP-2402011-A1
优先权日:2004-08-25
标题:Intermediates in the synthesis of S-triazolyl alpha-mercaptoacetanildes as inhibitors of HIV reverse transcriptase

专利号:NZ-581376-A
优先权日:2004-08-25
标题 :Intermediates useful in the synthesis of S-triazolyl alpha-mercaptoacetanildes for inhibition of HIV reverse transcriptase

专利号:SA-115360678-B1
优先权日:2012-07-03
标题:Synthesis of 2-(5-bromo-4-(4-cyclopropylnaphthalene-1-yl)-4H-1,2,4-Trazol-3-ylthio)acetic acid