CAS: 140-38-5; 1-(4-Chlorophenyl)Urea

相似化合物

2327-02-8 13208-51-0 5352-88-5

上下游产品

CAS号13463-94-0 (4-chlorophenyl... | CAS号590-28-3 氰酸钾 | CAS号106-47-8 对氯苯胺 | CAS号917-61-3 氰酸钠 | CAS号88220-42-2 4-[N-[N-(4-chlo... | CAS号130974-86-6 (E)-1-(4-氯苯基)-2-羟基胍 | CAS号64-10-8 N-苯基脲 | CAS号61706-59-0 sodium fulminate | CAS号3696-23-9 4-氯苯基硫脲 | CAS号104-12-1 4-氯苯基异氰酸酯 | CAS号35367-38-5 氟脲杀 | CAS号122987-01-3 N-(4-氯苯基)-2,6-二氟苯甲酰胺 | CAS号52112-68-2 2-氨基-6-氯苯并恶唑 | CAS号102395-63-1 ethyl 1-[(4-chl... | CAS号101080-71-1 1-(4-chlorophen... | CAS号150-68-5 1,1-二甲基-3-(对氯苯基)脲 | CAS号32772-86-4 Acetamide,N-[[(... | CAS号13620-47-8 1-(2-chloroacet... | CAS号106-47-8 对氯苯胺 | CAS号463-77-4 氨基甲酸

苯基脲置于氯,溶剂黄146体系中,用23 %的收率获得4-氯苯基脲
参考文献:一种2,4-二氯苯胺/肼的制备方法
标题:一种2,4-二氯苯胺/肼的制备方法
摘要:本发明公开了一种2,4‑二氯苯胺/肼的制备方法,以苯脲为原料,通过双氯代反应,水解反应,高收率地获得2,4‑二氯苯胺或2,4‑二氯苯胺盐酸盐,并用于2,4‑二氯苯肼盐酸盐的制备.

专利信息

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-2025098683-A1
优先权日:2023-11-10
标 题:Improved process for the synthesis of imepitoin
发明人：ESTEVEZ LORA RAÚL; GARCÃ?A RAMOS Ã?LVARO; MARTINEZ GRAU MARÃ?A Ã?NGELES
权利人:JUSTESA IMAGEN S A U
摘要:The present invention describes an improved process for the preparation of imepitoin by means of an efficient preparation of its intermediate 1-(4- chlorophenyl)imidazolidine-2,4-dione followed by condensation with morpholine in the presence of ammonium chloride. Particularly, the invention relates to a process which provides imepitoin in high yield by removing the water generated in the reaction using a continuous process to distil, dry and recirculate the dried morpholine back to the reactor. More particularly, the invention relates to a process that provides imepitoin with very high purity by a simple washing with toluene and water. Still more particularly, the invention relates to a cost-effective process that is scalable for industrial application.

专利号:EP-4553066-A1
优先权日:2023-11-10
标题 :Improved process for the synthesis of imepitoin

专利号:IT-202100000782-A1
优先权日:2021-01-18
标 题 :PROCESS FOR THE SYNTHESIS OF IMEPITOIN

专利号:EP-4277899-A1
优先权日:2021-01-18
标 题:Process for the synthesis of imepitoin

专利号:CN-101565391-A
优先权日:2009-05-18
标 题 :One-pot synthesis of N, N'-di (p-chlorophenyl) urea and preparation of 2, 4-dichloroaniline