CAS: 145040-37-5; 1-(((Cyclohexyloxy)Carbonyl)Oxy)Ethyl 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]Imidazole-7-Carboxylate

上下游产品

CAS号170791-09-0 三苯甲基坎地沙坦西来替昔酯 | CAS号99464-83-2 1-氯乙基环己基碳酸酯 | CAS号18162-48-6 叔丁基二甲基氯硅烷 | CAS号139481-59-7 坎地沙坦 | CAS号632322-62-4 1-(cyclohexylox... | CAS号78-09-1 原碳酸四乙酯 | CAS号1236156-65-2 (+/-)-1-[[(cycl... | CAS号139481-72-4 三苯甲基坎地沙坦 | CAS号170791-09-0 三苯甲基坎地沙坦西来替昔酯 | CAS号869631-11-8 O-去乙基坎地沙坦 | CAS号914613-36-8 坎地沙坦西来替昔乙酯 | CAS号914613-35-7 1H-1-乙基坎地沙坦西来替昔酯

1-(((Cyclohexyloxy)Carbonyl)Oxy)Ethyl 2-Ethoxy-1-((2'-(1-(4-Methoxybenzyl)-1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate 以55的收率获得坎地沙坦酯
参考文献:Process For Production Of Biphenyl Derivative
标题:Process For Production Of Biphenyl Derivative
摘要:本发明提供了一种生产双芳基四唑衍生物的方法,该衍生物可用作血管紧张素ii受体拮抗剂的中间体.该方法包括将芳基四唑衍生物与苯衍生物反应,去保护或还原所得化合物,并卤代去保护或还原的化合物.

专利信息

专利号:US-2008214637-A1
优先权日:2004-11-11
标题 :Process for the Synthesis of Tetrazoles
发明人：ANTONCIC LJUBOMIR; LUDESCHER JOHANNES
权利人:LEK PHARMACEUTICALS
摘要:A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2025223262-A1
优先权日:2022-03-31
标 题 :Synthesis of morphinans with reduced herg activity and mop binding
发明人：LAMMERT ECKHARD; SCHOLZ OKKA; OTTER SILKE; HEREBIAN DIRAN; HOFFMANN TORSTEN; SANZ MIGUEL ANGEL; KRAMP LAURENZ; LEVY LAURA MARIANA; HRISTEVA STANIMIRA
权利人:HEINRICH HEINE UNIV DUESSELDORF; DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT E V; TAROS CHEMICALS GMBH & CO KG
摘要:The invention relates to morphinan-derivatives, processes for their preparation, medicaments containing them and the use of these morphinan-derivatives for the preparation of medicaments.

专利号:US-7098342-B2
优先权日:2003-10-16
标题 :Preparation of candesartan cilexetil
发明人：ETINGER MARINA YU; FEDOTEV BORIS; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.

专利号:WO-2008012852-A1
优先权日:2006-07-27
标 题:Intermediate compounds for the preparation of angiotensin ii antagonists
发明人：GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.